Increased coronary mortality in relatives of hypercholesterolemic school children: the Muscatine study.
Increased coronary mortality in relatives of hypercholesterolemic school children: the Muscatine study.
复制标题
高胆固醇血症学童亲属的冠状动脉死亡率增加：马斯卡廷研究。
作者：
H. Schrott;W. Clarke;D. Wiebe;W. Connor;R. Lauer;Kathleen M. Schreiber;Joy S. Eyman
我们从参加 1971 年和 1973 年马斯卡廷冠状动脉危险因素调查的 2,874 名学童中，选择了三组指标病例进行详细的家庭研究： HIGH 组（n = 56），胆固醇水平高于 95% 的两倍；中组 (n = 46)，胆固醇水平在第 5 个百分位数和第 95 个百分位数之间；低水平组（n = 46）的胆固醇水平低于第 5 个百分位数两倍。根据死亡证明确定的 HIGH 组指数病例的年轻亲属（30-59 岁）的冠状动脉死亡率增加，如下：与 MIDDLE 或 LOW 组相比，HIGH 男性亲属高出两倍（p 小于 0.05）；与中组和低组的总和相比，高组女性亲属的患病率高出十倍（p 小于 0.01）。经过多年的风险校正后，冠心病死亡率显着增加了大约两倍。 HIGH 指数病例的年长亲属（年龄大于或等于 60 岁）的中风死亡率较高，但并不显着。三组指标病例亲属的癌症死亡率没有显着差异。这项研究表明，学童的胆固醇水平与其家庭成员的胆固醇水平相似，并且儿童持续的高胆固醇血症表明家庭有患冠状动脉疾病的风险。
From 2,874 school children participating in the 1971 and 1973 Muscatine Coronary Risk Factor Survey, we selected three groups of index cases for detailed family study: the HIGH group (n = 56), with cholesterol levels greater than the 95th percentile twice; the MIDDLE group (n = 46), cholesterol levels between the 5th and 95th percentile; and the LOW group (n = 46), cholesterol levels less than the 5th percentile twice. Coronary mortality determined from death certificates was increased in the young relatives (ages 30-59) of the HIGH group index cases, as follows: twofold excess in HIGH male relatives compared with the MIDDLE or LOW group (p less than 0.05); tenfold excess in the HIGH female relatives compared with the MIDDLE and LOW group combined (p less than 0.01). After correction for years at risk, there was an approximately twofold significantly-increased coronary mortality. Stroke mortality was higher, although not significantly, in the older relatives (ages greater than or equal to 60) of the HIGH index cases. Cancer mortality was not significantly different among the relatives of the three groups of index cases. This study indicates that school children's cholesterol levels cluster with those of their family members and that persistent hypercholesterolemia in children identifies families at risk for coronary artery disease.