Rhein stimulates active chloride secretion in the short-circuited rat colonic mucosa.
Rhein stimulates active chloride secretion in the short-circuited rat colonic mucosa.
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DOI：
10.1159/000138429
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发表时间：
1988
期刊：
影响因子：
3.1
通讯作者：
K. Goerg;R. Wanitschke;M. Schwarz;K. Meyer zum Büschenfelde
中科院分区：
文献类型：
--
作者：
K. Goerg;R. Wanitschke;M. Schwarz;K. Meyer zum Büschenfelde
在一个短路的粘膜-粘膜下层制备的大鼠降结肠与保存迈斯纳氏丛安装作为外翻囊大黄酸短暂增加的电位差和短路电流（Isc）时，给药serosally和mucosally，但serovirus应用程序更有效。在大黄酸浓度为1.6 × 10 ~（-4）和3 × 10 ~（-4）mol/l时，作用最大。净氯吸收减少。吲哚美辛（5 × 10（-6）mol/l）不能抑制Isc的增加，但从Serbine侧去除钙以及Tetrodoxin（2 × 10（-7）mol/l）使Isc降低50%和60%。机械切除触觉神经丛也部分阻断了大黄酸的作用。结论：大黄酸通过直接作用于上皮细胞，并通过神经体液机制间接刺激结肠分泌。
In a short-circuited mucosa-submucosa preparation of the rat descending colon with preserved Meissner's plexus mounted as an everted sac rhein transiently increased the potential difference and short-circuit current (Isc) when administered serosally and mucosally, but serosal application was more effective. Maximal effects were obtained at rhein concentrations of 1.6 X 10(-4) and 3 X 10(-4) mol/l. Net chloride absorption was decreased. Indomethacin (5 X 10(-6) mol/l) did not inhibit the increase of Isc, but omission of calcium from the serosal side as well as tetrodoxin (2 X 10(-7) mol/l) decreased it by 50 and 60%. Mechanical removal of Meissner's plexus partly blocked the effect of rhein, too. It is concluded that rhein stimulates colonic secretion by a direct action on the epithelial cells together with an indirect action via neurohumoral mechanisms.