RENAL AND NEPHRON HEMODYNAMICS IN SPONTANEOUSLY HYPERTENSIVE RATS
RENAL AND NEPHRON HEMODYNAMICS IN SPONTANEOUSLY HYPERTENSIVE RATS
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DOI：
10.1152/ajprenal.1979.236.3.f246
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发表时间：
1979-01-01
影响因子：
--
通讯作者：
BEIERWALTES, WH
中科院分区：
文献类型：
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作者：
ARENDSHORST, WJ;BEIERWALTES, WH
本文比较了麻醉、非利尿、自发性高血压大鼠（SHR）和WKY大鼠（WKY）的肾脏和肾单位血流动力学。虽然SHR的平均动脉压高于WKY，158与114 mm Hg，但两组的肾小球滤过率（GFR）、肾血流量（RBF）、肾内静水压力、单肾单位GFR（SNGFR）和单肾单位血流量（SNBF）相似。SHR的肾血管阻力（RVR）增加是由于肾小球前血管收缩占主导地位。在第二组SHR，SHR-AC，股动脉压降低到114毫米汞柱的主动脉收缩以上的肾动脉。GFR、RBF、SNGFR、SNBF和肾内流体静压的平均值与SHR相似，而SHR-AC的RVR较低。RVR的自身调节主要局限于肾小球前血管。所有3组的传出小动脉阻力相似。12周龄SHR的RVR增强主要是由于传入小动脉阻力对动脉压升高的生理性自动调节反应。SHR的RVR不是固定不变的，而是对降低的肾灌注压有反应。
Renal and nephron hemodynamics of anesthetized, nondiuretic, spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) were compared. Although the mean arterial pressure was higher in SHR than in WKY, 158 vs. 114 mm Hg, glomerular filtration rate (GFR), renal blood flow (RBF), intrarenal hydrostatic pressures, single nephron GFR (SNGFR), and single nephron blood flow (SNBF) were similar in both groups. Increased renal vascular resistance (RVR) in SHR was due to predominant preglomerular vasoconstriction. In a 2nd group of SHR, SHR-AC, femoral arterial pressure was reduced to 114 mm Hg by aortic constriction above the renal arteries. Mean values for GFR, RBF, SNGFR, SNBF and intrarenal hydrostatic pressure resembled SHR, and RVR was less in SHR-AC. Autoregulatory adjustments of RVR were largely limited to preglomerular vasculature. Efferent arteriolar resistance was similar in all 3 groups. Enhanced RVR in 12 wk old SHR is primarily due to physiological, autoregulatory response of afferent arteriolar resistance to elevated arterial pressure. RVR in SHR is not fixed and constant but responds to reduced renal perfusion pressure.