Birth weight and sex of children and the correlation to the body burden of PCDDs/PCDFs and PCBs of the mother.
Birth weight and sex of children and the correlation to the body burden of PCDDs/PCDFs and PCBs of the mother.
复制标题
儿童出生体重和性别与母亲体内PCDDs/PCDFs和PCBs负荷的相关性。
DOI：
10.1289/ehp.9810661
复制
发表时间：
1998-02
影响因子：
10.4
通讯作者：
Tuomisto J
中科院分区：
文献类型：
--
作者：
Vartiainen T;Jaakkola JJ;Saarikoski S;Tuomisto J
多氯二苯并对二恶英（PCDDs），多氯二苯并呋喃（PCDFs），多氯联苯（PCBs）进行了分析，在167个随机母乳样本从城市和农村地区在芬兰。通过问卷调查收集每个母亲和孩子的饮食习惯和背景信息。农村妇女孕前和分娩前的体重指数（BMI）比城市妇女高5-10%，而母乳脂肪含量比城市妇女高10%左右。农村和城市地区的儿童平均体重（+/-标准差）在小岛屿发展中国家之间相似，分别为3，500 +/- 597克和3，505 +/- 454克，尽管城市地区的二恶英国际毒性当量（I-TEQs）要高得多。母亲的教育水平并不影响儿童的体重，但多氯二苯并对二恶英/多氯二苯并呋喃（I-TEQ、2，3，4，7，8-Cl 5二苯并呋喃、1，2，3，7，8-Cl 5二苯并二恶英）和多氯联苯[多氯联苯总量（多氯联苯总量）、多氯二苯并对二恶英和大多数多氯联苯同系物]的浓度随着教育水平的提高而增加。这被认为是由于母亲对鱼的消费量不同。随着毒性当量、2，3，4，7，8-Cl 5二苯并呋喃、1，2，3，7，8-Cl 5二苯并二恶英和2，3，7，8-Cl 4二苯并二恶英浓度的增加，出生体重（尤其是男孩的出生体重）略有下降;然而，当分析仅限于鱼时，出生体重与多氯二苯并对二恶英/多氯二苯并呋喃浓度之间没有统计学上的显著相关性。没有发现相关性之间的体重的儿童和多氯联苯，多氯联苯毒性当量，或个别多氯联苯同源物在整个材料或之间，或在男孩或女孩。PCDDs/PCDFs和多氯联苯的浓度为人乳中的体重鱼消费量，母亲的年龄，牛奶脂肪含量，和BMI怀孕前的模拟。线性回归导致的R值= 0.67和0.30的模拟二恶英的I-TEQs在城市和农村地区，分别和相应的值为总多氯联苯的R = 0.60和0.11。多氯二苯并对二恶英/多氯二苯并呋喃体内负荷的增加量在城市地区平均为0.58皮克毒性当量/克乳脂/年，在农村地区为0.39皮克毒性当量/克乳脂/年。
Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) were analyzed in 167 random human milk samples from urban and rural areas in Finland. Dietary habits and background information on each mother and child were gathered by questionnaire. Body mass indexes (BMI) before pregnancy and delivery in the rural area were 5-10% higher than in the urban area, but fat content of mother's milk was about 10% higher in the urban area. The mean weights of children (+/- standard deviation) were similar in the rural and urban areas among primiparae, 3,500 +/- 597 g and 3,505 +/- 454 g, respectively, although dioxin international toxic equivalents (I-TEQs) were significantly higher in the urban area. The mother's level of education did not affect the weight of the child, but concentrations of PCDDs/PCDFs (I-TEQ, 2,3,4,7,8-Cl5 dibenzofuran,1,2, 3,7,8-Cl5 dibenzodioxin) and PCBs [sum of PCBs (sumPCB), PCB-TEQ, and most PCB congeners] increased with advanced education. This is considered to be due to differences in the mother's consumption of fish. The birth weight, especially of boys, slightly decreased with increasing concentrations of I-TEQ, 2,3,4,7,8-Cl5 dibenzofuran, 1,2,3, 7,8-Cl5 dibenzodioxin, and 2,3,7,8-Cl4 dibenzodioxin; however, when the analysis was restricted to primiparae, there was no statistically significant correlation between birth weight and the concentrations of PCDDs/PCDFs. No correlation was found between the weight of the child and PCBs, PCB-TEQs, or individual PCB congeners in the whole material or among primiparae, or among boys or girls. The concentrations of PCDDs/PCDFs and PCBs inhuman milk were modeled for primiparae by weighing fish consumption, age of mother, milk fat content, and BMI before pregnancy. The linear regression resulted in values of R = 0.67 and 0.30 for the modeled dioxin I-TEQs in the urban and rural areas, respectively, and the corresponding values for sumPCBs of R = 0.60 and 0.11. The increase of PCDD/PCDF body burden was calculated to be on average 0.58 pg I-TEQ/g milk fat/year in the urban area and 0.39 pg I-TEQ/g milk fat/year in the rural area.