Exploitation of host cells by Burkholderia pseudomallei.
Exploitation of host cells by Burkholderia pseudomallei.
复制标题
鼻疽伯克霍尔德氏菌对宿主细胞的利用。
DOI：
10.1078/1438-4221-00292
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
E. Galyov
中科院分区：
文献类型：
--
作者：
M. Stevens;E. Galyov
细胞内细菌病原体已经进化出利用肌动蛋白聚合的力量进入和离开真核细胞的机制，并破坏细胞酶和信号转导途径的活性。细菌用来破坏细胞过程的蛋白质通常在结构或功能上模仿真核蛋白质。类鼻疽是热带和亚热带地区流行的一种严重的动物和人类侵袭性疾病，近年来对类鼻疽的研究为类鼻疽的发病机制提供了新的视角。B。类鼻疽可以侵入上皮细胞，在吞噬细胞内存活和增殖，从内吞囊泡中逃逸，形成基于肌动蛋白的膜突起并诱导宿主细胞融合。在这里，我们审查目前的理解这些过程的分子机制。
Intracellular bacterial pathogens have evolved mechanisms to enter and exit eukaryotic cells using the power of actin polymerisation and to subvert the activity of cellular enzymes and signal transduction pathways. The proteins deployed by bacteria to subvert cellular processes often mimic eukaryotic proteins in their structure or function. Studies on the exploitation of host cells by the facultative intracellular pathogen Burkholderia pseudomallei are providing novel insights into the pathogenesis of melioidosis, a serious invasive disease of animals and humans that is endemic in tropical and subtropical areas. B. pseudomallei can invade epithelial cells, survive and proliferate inside phagocytes, escape from endocytic vesicles, form actin-based membrane protrusions and induce host cell fusion. Here we review current understanding of the molecular mechanisms underlying these processes.
影响因子：
3.6
作者：
Zhou, DG;Chen, LM;Galán, JE
通讯作者：
Galán, JE
DOI：
10.1073/pnas.89.24.11939
发表时间：
1992-12-15
影响因子：
11.1
作者：
GROISMAN, EA;PARRALOPEZ, C;HEFFRON, F
通讯作者：
HEFFRON, F