Pediatric mechanical circulatory support.
Pediatric mechanical circulatory support.
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DOI：
10.5090/kjtcs.2013.46.6.391
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Morales D
中科院分区：
文献类型：
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作者：
Wilmot I;Lorts A;Morales D
机械循环支持（MCS）在儿科心力衰竭人群中的应用历史有限，尤其是在婴儿和新生儿中。越来越多的人认识到，被诊断患有心力衰竭的儿童人数迅速增加。这一不断扩大的人口导致越来越多的儿童患有耐药性终末期心力衰竭。这些儿童的传统治疗方法是心脏移植。然而，与成人不同，心力衰竭儿童在出现终末期心力衰竭之前没有症状，因此不能安全地等待移植。这些儿童中的许多人都是利用体外膜氧合作为心脏移植的桥梁，但效果不佳。因此，行业、临床医生和政府重新关注为心力衰竭儿童开发越来越多的MCS选择，作为移植的桥梁和慢性治疗。在这篇综述中，我们讨论了目前可用于终末期心力衰竭婴儿和儿童的短期和长期支持的MCS选择。
Mechanical circulatory support (MCS) in the pediatric heart failure population has a limited history especially for infants, and neonates. It has been increasingly recognized that there is a rapidly expanding population of children diagnosed and living with heart failure. This expanding population has resulted in increasing numbers of children with medically resistant end-stage heart failure. The traditional therapy for these children has been heart transplantation. However, children with heart failure unlike adults do not have symptoms until they present with end-stage heart failure and therefore, cannot safely wait for transplantation. Many of these children were bridged to heart transplantation utilizing extracorporeal membranous oxygenation as a bridge to transplant which has yielded poor results. As such, industry, clinicians, and the government have refocused interest in developing increasing numbers of MCS options for children living with heart failure as a bridge to transplantation and as a chronic therapy. In this review, we discuss MCS options for short and long-term support that are currently available for infants and children with end-stage heart failure.