Linear Alternating Supramolecular Photosensitizer for Enhanced Photodynamic Therapy
Linear Alternating Supramolecular Photosensitizer for Enhanced Photodynamic Therapy
复制标题
用于增强光动力治疗的线性交替超分子光敏剂
DOI：
10.1021/acsami.0c07333
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发表时间：
2020
影响因子：
9.5
通讯作者：
Zhang Weian
中科院分区：
文献类型：
--
作者：
Tian Jia;Xia Lei;Wu Jian;Huang Baoxuan;Cao Hongliang;Zhang Weian
超分子聚合物通过非共价键连接，具有简单多样的结构，在生物领域具有巨大的潜力。本文通过环糊精二聚体(CD2)与双官能团金刚烷共轭卟啉(TPP-AD2)之间的主客体包合作用，构建了一种线性交替超分子聚合物。Cd/TPP的超分子交替结构不仅可以通过空间位阻抑制PSS的聚集，提高PSS的光物理性能，而且可以提高由环糊精部分诱导的PSS的水溶性。这种线性交替超分子聚合物(TPP-AD2/CD2)得到的纳米平台具有显著增强的光动力疗法(PDT)效果，为光动力疗法提供了一条有前景的途径。
Supramolecular polymers with facile and versatile architectures via noncovalent connection present great potential in biological fields. Herein, a linear alternating supramolecular polymer is constructed via host–guest inclusion interaction between cyclodextrin dimer (CD2) and bifunctional adamantane-conjugated porphyrin (TPP-Ad2). The supramolecular alternating structure of CD/TPP could not only suppress the aggregation of PSs to improve the photophysical properties because of the steric hindrance but also enhance the water solubility of PSs induced from cyclodextrin moieties. The nanoplatform obtained by this linear alternating supramolecular polymer (TPP-Ad2/CD2) presents significantly enhanced photodynamic therapy (PDT) efficacy, providing a promising path for PDT.