Asymptomatic cardiac ischemia pilot (ACIP) study two-year follow-up - Outcomes of patients randomized to initial strategies of medical therapy versus revascularization
Asymptomatic cardiac ischemia pilot (ACIP) study two-year follow-up - Outcomes of patients randomized to initial strategies of medical therapy versus revascularization
复制标题
DOI：
10.1161/01.cir.95.8.2037
复制
发表时间：
1997-04-15
期刊：
影响因子：
37.8
通讯作者：
Conti, CR
中科院分区：
文献类型：
--
作者：
Davies, RF;Goldberg, AD;Conti, CR
背景在负荷试验和动态心电图监测期间出现缺血的患者发生心脏事件的风险增加，但尚不清楚是否通过使用抗缺血药物或血运重建进行更积极的治疗来改善其预后。方法和结果无症状心脏缺血先导性研究将558例冠状动脉解剖结构适合血运重建的患者随机分为三种治疗策略：心绞痛引导的药物治疗（n=183），心绞痛加缺血引导的药物治疗（n=183），或通过血管成形术或旁路手术进行血运重建（n=192）。随机分组后2年，心绞痛指导策略的总死亡率为6.6%，缺血指导策略为4.4%，血运重建策略为1.1%（P
Background Patients with ischemia during stress testing and ambulatory ECG monitoring have an increased risk of cardiac events, but it is not known whether their prognosis is improved by more aggressive treatment with anti-ischemic drugs or revascularization.Methods and Results The Asymptomatic Cardiac Ischemia Pilot study randomized 558 such patients who had coronary anatomy suitable for revascularization to three treatment strategies: angina-guided drug therapy (n=183), angina plus ischemia-guided drug therapy (n=183), or revascularization by angioplasty or bypass surgery (n=192). Two years after randomization, the total mortality was 6.6% in the angina-guided strategy, 4.4% in the ischemia-guided strategy, and 1.1% in the revascularization strategy (P