Oxidants, antioxidants, and respiratory tract lining fluids.
Oxidants, antioxidants, and respiratory tract lining fluids.
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DOI：
10.1289/ehp.94102s10185
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发表时间：
1994-12
影响因子：
10.4
通讯作者：
Halliwell B
中科院分区：
文献类型：
--
作者：
Cross CE;van der Vliet A;O'Neill CA;Louie S;Halliwell B
呼吸道衬里液（RTLF）是覆盖从鼻粘膜到肺泡的呼吸道上皮细胞（RTEC）的一组异质性物质。RTLF中所含的抗氧化剂可以预期提供对吸入的环境毒素的初始防御。RTLF中的主要抗氧化剂包括粘蛋白、尿酸、蛋白质（主要是白蛋白）、抗坏血酸和还原型谷胱甘肽（GSH）。RTLF抗氧化剂可以通过诸如血浆成分的渗出/渗出; RTEC分泌过程，包括腺粘液分泌;以及源自RTEC和炎性细胞裂解的细胞抗氧化剂等过程来增强。RTLFs的抗氧化成分及其在氧化应激条件下调节正常和病理生理RTEC功能的作用尚未完全表征。
Respiratory tract lining fluids (RTLFs) are a heterogeneous group of substances covering the respiratory tract epithelial cells (RTECs) from nasal mucosa to alveoli. Antioxidant contained in the RTLFs can be expected to provide an initial defense against inhaled environmental toxins. The major antioxidants in RTLF include mucin, uric acid, protein (largely albumin), ascorbic acid, and reduced glutathione (GSH). RTLF antioxidants can be augmented by such processes as transudation/exudation of plasma constituents; RTEC secretory processes, including glandular mucus secretion; and cellular antioxidants derived from lysis of RTECs and of inflammatory cells. The antioxidant composition of RTLFs and their role in modulating normal and pathophysiologic RTEC functions under conditions of oxidative stress are yet to be fully characterized.