The impact of lymph node involvement on survival in patients with papillary and follicular thyroid carcinoma
The impact of lymph node involvement on survival in patients with papillary and follicular thyroid carcinoma
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DOI：
10.1016/j.surg.2008.08.034
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发表时间：
2008-12-01
期刊：
影响因子：
3.8
通讯作者：
Phay, John E.
中科院分区：
文献类型：
--
作者：
Zaydfudim, Victor;Feurer, Irene D.;Phay, John E.
背景资料。在高分化甲状腺癌中，淋巴结转移对预后的影响仍存在争议。我们调查了高分化甲状腺癌患者的淋巴结转移对生存率的影响。我们查询了1988-2003年间诊断为高分化甲状腺癌患者的监测、流行病学和最终结果登记。病例按年龄(=45岁)和病理(乳头状/滤泡状)分层。建立了四个独立的COX回归模型，以检验人口统计学和临床协变量对生存的影响。我们确定了33,088名患者。乳头状癌30,504例(49%)，滤泡性癌2,584例(55%)。年龄影响所有模型的存活率(P<；.001)。在……里面。乳头状癌患者年龄=45岁，淋巴结受累与46%的患者死亡风险增加相关(P
Background. The prognostic role of lymph node metastases in well-differentiated thyroid carcinoma remains controversial. We investigated impact of lymph node involvement on survival in patients with well-differentiated thyroid cancer.Methods. We queried the Surveillance, Epidemiology, and End Results registry for patients diagnosed with well-differentiated thyroid carcinoma between 1988 and 2003. Cases were stratified by age (= 45 years) and pathology (Papillary/follicular). Four separate Cox regression models were developed to test the effects of demographic and clinical covariates on survival.Results. We identified 33,088 patients. 30,504 patients (49% >= 45 years) had papillary carcinoma and 2,584 patients (55% >= 45 years) had follicular carcinoma. Age affected survival in all models (P < .001). In. patients with papillary carcinoma = 45 years, lymph node involvement was associated with 46% increased,risk of death (P