Predictors of outcome in LAAM, buprenorphine, and methadone treatment for opioid dependence
Predictors of outcome in LAAM, buprenorphine, and methadone treatment for opioid dependence
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DOI：
10.1037/1064-1297.13.4.293
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发表时间：
2005-11-01
影响因子：
2.3
通讯作者：
Johnson, RE
中科院分区：
文献类型：
--
作者：
Marsch, LA;Stephens, MAC;Johnson, RE
这项研究考察了(1)在比较美沙酮、丁丙诺啡和LAAM治疗的单地点对照试验中，阿片依赖参与者的治疗结果的预测因素，以及(2)不同亚群的患者使用每种药物可能获得更成功结果的程度。评估了患者人口统计学、药物使用史和心理状态之间的关系，以及治疗保留、阿片类药物使用和可卡因使用等结果指标。我们相信，这项研究首次证明，在LAAM、丁丙诺啡和美沙酮治疗阿片类药物依赖方面，治疗成功的预测因素似乎基本相似。我们没有发现任何强烈地指导选择一种药物而不是其他药物的因素。
This study examined (1) predictors of treatment outcome for opioid-dependent participants in a single-site controlled trial comparing methadone, buprenorphine, and LAAM treatments and (2) the extent to which various subpopulations of patients may have more successful outcomes with each medication. The relationships between patient demographics, drug use history, and psychological status and outcome measures of treatment retention, opiate use, and cocaine use were assessed. We believe this study to be the first to demonstrate that predictors of treatment success appear to be largely similar in LAAM, buprenorphine, and methadone treatment for opioid dependence. We did not find any factors that would strongly guide selection of one medication over others.