Thermal Damage and Rate Processes in Biologic Tissues
Thermal Damage and Rate Processes in Biologic Tissues
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DOI：
10.1007/978-90-481-8831-4_13
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Pearce, John A.
中科院分区：
文献类型：
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作者：
Thomsen, Sharon;Pearce, John A.
通过吸收光能并将其转化为热能，在激光照射的组织中产生热量。一旦在组织内产生，热量就是热量，无论使用什么原始能源来产生热量。细胞和生物组织的加热会产生可逆的损伤和功能障碍，可以通过先天细胞和宿主机制进行修复。然而，更严重的、不可逆转的损害会导致加热事件立即（主要热效应）或之后（延迟二次效应）死亡。有时，在加热时不容易观察到活组织中可逆（可修复）和不可逆（致命）损伤之间的分界线。因此，为了准确确定有效（杀死）热处理的程度，观察者必须等待所有垂死的、受伤的细胞死亡并经历死后坏死（两到四天）[1-6]。
Heat is generated in laser irradiated tissues by absorption and transformation of the light energy into heat. Once generated within tissues, heat is heat no matter what original energy source is used to produce it. Heating of cells and biological tissues can produce reversible injury and dysfunction that can be repaired by innate cellular and host mechanisms. However, more severe, irreversible damage leads to death immediately (primary thermal effects) or after (delayed secondary effects) the heating event. Sometimes, the dividing line between reversible (repairable) and irreversible (lethal) damage in living, surviving tissues is not easily observed at the time of heating. Therefore, to determine accurately the extent of effective (killing) thermal treatment, the observer has to wait for all the moribund, injured cells to die and undergo post-mortem necrosis (two-four days) [1–6].