Age-related macrophage alterations are associated with carcinogenesis of colorectal cancer
Age-related macrophage alterations are associated with carcinogenesis of colorectal cancer
复制标题
年龄相关的巨噬细胞改变与结直肠癌的发生有关
DOI：
10.1093/carcin/bgac088
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发表时间：
2022
期刊：
影响因子：
4.7
通讯作者：
Hongxia Zhu
中科院分区：
文献类型：
--
作者：
Yinuo Li;Yahui Zhao;Yang Gao;Yu Li;Mei Liu;Ningzhi Xu;Hongxia Zhu
Abstract. Older age is a major risk factor for colorectal cancer. Macrophage is one of the most abundant immune cell types infiltrated in colorectal cancer, but the contribution of macrophages in elder tumor microenvironment is far from clear. In this study, we first detected the expression of CD206, CD68 in colorectal cancer tissues by multiplex fluorescence immunohistochemical staining. The infiltration of CD68 +/CD206 + cells in tumor tissues from old patients was higher than those from young patients. When mixed with CT26 cells, both young and aged TAMs enhanced tumor growth of CT26 cells, but CT26 mixed with aged TAMs form larger tumors compared with young TAMs. CT26 formed more and larger tumors in the abdominal cavity of aged mice compared with young. Total macrophage infiltration and the CD206 + macrophages infiltration were both higher in aged mice compared with young mice. The expression signatures of tumor associated macrophages altered with ageing and p-NF-κB translocation to nucleus was more significant in TAMs from aged mice compared with young. Our results showed that infiltration of macrophages in colorectal cancer tissues increased with ageing. Macrophages from aged host were more likely to polarize to pro-tumor phenotype, and more powerful in promoting tumor cell proliferation.
