Effects of strontium on the quality of bone apatite crystals: a paired biopsy study in postmenopausal osteoporotic women
Effects of strontium on the quality of bone apatite crystals: a paired biopsy study in postmenopausal osteoporotic women
复制标题
锶对骨磷灰石晶体质量的影响：绝经后骨质疏松妇女的配对活检研究
作者：
Audrey Doublier;Audrey Doublier;D. Farlay;D. Farlay;X. Jaurand;R. Vera;G. Boivin;G. Boivin
在接受雷奈酸锶或安慰剂治疗36个月的骨质疏松症妇女的配对活组织检查中，骨磷灰石晶体的特征不受锶存在的影响。锶离子取代钙的平均率为4.5%。在接受雷奈酸锶（SrRan）或安慰剂治疗36个月的骨质疏松症妇女的配对活组织检查中，研究了锶（Sr）对骨磷灰石晶体的潜在影响。方法采用x射线衍射和选择区域电子衍射对10例成对活检组织的结晶度、晶体的表观长度和宽度/厚度、面间距离和单位细胞的晶格参数进行评价。结果在治疗36个月后，SrRan组和安慰剂组反映晶体和单位细胞特征的所有参数均不受Sr存在的影响。锶离子取代钙的平均率为4.5%。结论SrRan治疗36个月后，骨磷灰石晶体质量总体保持不变。
SummaryIn paired biopsies of osteoporotic women treated with either strontium ranelate or a placebo for 36 months, characteristics of bone apatite crystals were not influenced by the presence of strontium. The mean rate of substitutions of calcium by strontium ions was 4.5 %.IntroductionThe potential effect of strontium (Sr) on bone apatite crystals was investigated in paired biopsies of osteoporotic women treated with either strontium ranelate (SrRan) or a placebo for 36 months.MethodsIn ten paired biopsies, crystallinity, apparent length and width/thickness of crystals, interplanar distances, and lattice parameters of unit cells were assessed by X-ray diffraction and selected area electron diffraction.ResultsAll these parameters, reflecting crystal and unit cell characteristics, were not influenced by the presence of Sr and were similar in SrRan and placebo groups after 36 months of treatment. The mean rate of substitutions of calcium by Sr ions was 4.5 %.ConclusionOverall, the quality of bone apatite crystals was maintained after 36 months of treatment with SrRan.