The evolution of costly resistance in host-parasite systems
The evolution of costly resistance in host-parasite systems
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DOI：
10.1086/303181
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发表时间：
1999-04-01
影响因子：
2.9
通讯作者：
Haraguchi, Y
中科院分区：
文献类型：
--
作者：
Boots, M;Haraguchi, Y
成对侵入性分析用于研究宿主对微寄生虫感染的抗性的进化动态。宿主的一系列菌株对感染的敏感性不同，敏感性较低的菌株付出代价，导致内在生长率较低。结合分析和图形的成对侵入性分析，我们表明，进化的结果取决于阻力之间的约束函数的形状和假设的成本在内在增长率。当抵抗的代价越来越大时，预测会有一个单一的进化稳定策略。或者，随着抗性代价的降低，我们发现宿主可以最大限度地抵抗或根本不抵抗。在某些条件下，这两种类型的二态性都存在，但中间抗性不发生。与所使用的权衡函数无关，当宿主的承载能力高时，我们总是更有可能获得宿主的抗性菌株。寄生虫的致病性在确定抗性的可能性和程度方面也很重要。
Pairwise invadability analysis is used to examine the evolutionary dynamics of host resistance to microparasitic infection. A continuum of strains of the host differs in susceptibility to infection, with less susceptible strains paying a cost resulting in a lower intrinsic growth rate. With a combination of analytical and graphical pairwise invadability analysis, we show that the evolutionary outcome depends crucially on the shape of the constraint function between resistance and its assumed cost in intrinsic growth rates. When resistance is increasingly costly, a single evolutionarily stable strategy is predicted. Alternatively, with decreasingly costly resistance, we find that the hosts lend to be maximally resistant or not at all resistant. There are conditions under which dimorphism of both these types exists but intermediate resistances do not occur. Independently of the trade-off function used, we are always more likely to get resistant strains of the host when the carrying capacity of the host is high. The pathogenicity of the parasite is also important in determining the likelihood and degree of resistance.