Spatial navigation in the Morris water maze: working and long lasting reference memories
Spatial navigation in the Morris water maze: working and long lasting reference memories
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DOI：
10.1016/j.neulet.2004.12.029
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发表时间：
2005-04-22
影响因子：
2.5
通讯作者：
Bucherelli, C
中科院分区：
文献类型：
--
作者：
Baldi, E;Efoudebe, M;Bucherelli, C
研究了70日龄雄性Long-Evans兜帽大鼠在Morris水迷宫(MWM)范式中的空间导航发育。在连续5天的训练中，大鼠每天训练10次。在每一次试验中测量逃避潜伏期。每天在每日试验之前和之后立即进行探头测试。此外，在第6天进行了最后一次探测。在前3天的训练中，逃避潜伏期逐渐缩短，在第4天和第5天显示出渐近的趋势。在第一次获取过程结束时进行的探测试验显示出明显的对目标象限的偏好，但在24天后给予的探测试验中没有回忆起这一信息。在延迟24小时后恢复的记忆痕迹是在三次会话中收到30次试验后才形成的。在采集过程结束时给出的探测试验测试了工作记忆的效率，而延迟24小时的探测试验反映了与长时间参考记忆相对应的更好地整合的空间信息。可以注意到，逃避潜伏期的逐渐缩短并不能很好地表达大鼠长期(巩固)参考记忆的演变。这种记忆只能通过在训练后以适当的延迟执行的探头测试来令人满意地测量。当解释老鼠在MWM中的表现时，这些考虑因素可能会有一些兴趣。(C)2004爱思唯尔爱尔兰有限公司。保留所有权利。
Spatial navigation development in the Morris water maze (MWM) paradigm was studied in 70-day-old male Long-Evans hooded rats. During 5 consecutive days, rats' training consisted of a daily block of 10 trials. Escape latency was measured in each trial. Probe testing was performed every day immediately before and after the daily block of trials. In addition, a final probe was performed on Day 6. During the first 3 days of training, the escape latency became progressively shorter, showing an asymptotic trend on Days 4 and 5. Probe trials administered at the end of the first acquisition sessions showed clear preference for the target quadrant but this information was not recalled at probe trials given 24 It later. The memory trace retrieved after 24-h delay was formed only after 30 trials received over three sessions. The probe trial given at the end of an acquisition session tests the efficiency of the working memory whereas the 24 h delayed probe trial reflects better-consolidated spatial information corresponding to long lasting reference memory. It can be noted that the progressive shortening of escape latencies does not express closely the evolution of the rat's long lasting (consolidated) reference memory. This memory can be satisfactorily measured only by probe testing performed at an adequate delay after training. These considerations may be of some interest when interpreting the rat's performance in the MWM. (c) 2004 Elsevier Ireland Ltd. All rights reserved.