Therapeutic and clinical applications of nitroxide compounds.
Therapeutic and clinical applications of nitroxide compounds.
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DOI：
10.1089/ars.2007.1722
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发表时间：
2007-10
影响因子：
6.6
通讯作者：
B. Soule;F. Hyodo;Ken-ichiro Matsumoto;N. Simone;J. Cook;M. Krishna;James B. Mitchell
中科院分区：
文献类型：
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作者：
B. Soule;F. Hyodo;Ken-ichiro Matsumoto;N. Simone;J. Cook;M. Krishna;James B. Mitchell
氮氧化合物多年来一直被用作生物物理工具，但直到最近 15-20 年，许多有趣的生化相互作用才被发现并用于治疗应用。通过改变氧化应激和改变组织的氧化还原状态，硝基氧能够与许多代谢过程相互作用并改变许多代谢过程。这种相互作用可用于治疗和研究用途，包括防止电离辐射、作为功能性磁共振成像探针、癌症预防和治疗、控制高血压和体重以及防止缺血/再灌注损伤造成的损害。尽管还有很多工作要做，但许多应用已经得到了深入研究，其中一些目前正在临床试验中进行测试。本文综述了氮氧化合物的治疗和研究用途，重点关注从最初开发到现代最先进试验的进展。
Nitroxide compounds have been used for many years as biophysical tools, but only during the past 15-20 years have the many interesting biochemical interactions been discovered and harnessed for therapeutic applications. By modifying oxidative stress and altering the redox status of tissues, nitroxides have the ability to interact with and alter many metabolic processes. This interaction can be exploited for therapeutic and research use, including protection against ionizing radiation, as probes in functional magnetic resonance imaging, cancer prevention and treatment, control of hypertension and weight, and protection from damage resulting from ischemia/reperfusion injury. Although much remains to be done, many applications have been well studied, and some are presently being tested in clinical trials. The therapeutic and research uses of nitroxides are reviewed here, with a focus on the progress from initial development to modern, state-of-the art trials.