Investigation of factor affecting health-related quality of life in head and neck cancer patients
Investigation of factor affecting health-related quality of life in head and neck cancer patients
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DOI：
10.1111/j.1741-2358.2012.00662.x
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发表时间：
2013-09-01
期刊：
影响因子：
2
通讯作者：
Taniguchi, Hisashi
中科院分区：
文献类型：
--
作者：
Morimata, Jien;Otomaru, Takafumi;Taniguchi, Hisashi
目的：头颈癌患者存在严重的生理、社会和心理疾病，影响其生活质量。本研究的目的是探讨影响口腔内修复患者HRQL的因素。背景：一些横断面研究已经进行了调查HRQL在HNC患者，但这些研究并没有详细报告因素如何影响的HRQL上颌骨切除术和下颌骨切除术和/或舌切除术患者。材料和方法：根据纳入和排除标准，对50例上颌骨切除术和50例下颌骨切除术和/或舌切除术的口内假体患者进行了华盛顿大学第4版生活质量问卷（日文版）。结果：上颌骨切除术患者中，病理诊断为恶性肿瘤者与良性肿瘤者之间、有牙颌者与无牙颌者之间的HRQL无显著性差异，而病理诊断为恶性肿瘤者与无牙颌者之间的HRQL无显著性差异。年龄、性别、颈淋巴结清扫术和放疗影响HRQL。在下颌骨切除和/或舌切除患者中，有牙和无牙患者的牙齿状况无显著差异。结论：影响上颌骨切除术患者HRQL的因素与下颌骨切除术和/或舌切除术患者不同。虽然他们戴着稳定的假体，我们仍然能够证明切除的大小，放疗和颈淋巴结清扫术影响HRQL。
Objectives: Head and neck cancer (HNC) patients have profound illness of physical, social and psychological factors that affects quality of life (QOL). The purpose of this study is to investigate the factors affecting HRQL in patients with intra-oral prostheses.Background: Some cross-sectional studies have been performed to investigate HRQL in patients with HNC, but these studies did not report in detail how factors affect the HRQL of maxillectomy and mandibulectomy and/or glossectomy patients.Materials and Methods: The University of Washington Quality of Life version 4 questionnaires (Japanese version) was administered to 50 maxillectomy and 50 mandibulectomy and/or glossectomy patients with intra-oral prostheses who were selected according to inclusion and exclusion criteria. Gathered data were statistically analyzed to investigate how a number of factors, namely, age, sex, pathologic diagnosis, neck dissection, resection size, radiotherapy and dental condition affect HRQL.Results: In the maxillectomy patients, there were no significant differences between malignant and benign tumor in pathological diagnosis or between dentate and edentulous in dental condition. Age, sex, neck dissection and radiotherapy affected HRQL. In the mandibulectomy and/or glossectomy patients, there was no significant difference between dentate and edentulous in dental condition. Age, sex, glossectomy, neck dissection and radiotherapy affected HRQL.Conclusions: The factors affecting HRQL in the maxillectomy patients were different from those in the mandibulectomy and/or glossectomy patients. Though they wore stable prostheses; we were still able to show that resection size, radiotherapy and neck dissection affected HRQL.