Exercise capacity is a predictor of cardiovascular events in patients with type 2 diabetes mellitus.
Exercise capacity is a predictor of cardiovascular events in patients with type 2 diabetes mellitus.
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DOI：
10.3132/dvdr.2006.030
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发表时间：
2006-12-01
影响因子：
2.4
通讯作者：
Schrier, Robert W
中科院分区：
文献类型：
--
作者：
Seyoum, Berhane;Estacio, Raymond O;Schrier, Robert W
通过呼出气体分析测量的峰值运动耗氧量（峰值 VO2）是一种准确、可重复且可靠的确定运动能力的方法。在这项研究中，468 名 2 型糖尿病患者接受了分级运动测试，以测量基线时的峰值摄氧量；该队列对心血管疾病（CVD）事件的发生情况进行了五年的跟踪调查。研究发现，与未发生 CVD 事件的患者相比，在五年随访期间发生 CVD 事件的患者基线峰值摄氧量显着降低 (p = 0.02)。按性别分析显示，发生 CVD 事件的男性患者的平均峰值 VO2 显着低于未发生 CVD 事件的男性患者的峰值 VO2 (p < 0.03)。多元 Cox 回归分析还显示低峰值摄氧量是一个独立因素。总之，运动期间峰值摄氧量降低的 2 型糖尿病患者未来发生 CVD 事件的可能性更大。
Peak exercise oxygen consumption (peak VO2), as measured by expired gas analysis, is an accurate, reproducible and reliable method for determining exercise capacity. In this study, a cohort of 468 patients with type 2 diabetes underwent graded exercise testing to measure peak VO2 at baseline; the cohort was followed for five years for the occurrence of cardiovascular disease (CVD) events. Patients who developed CVD events during the five-year follow-up period were found to have significantly lower baseline peak VO2, as compared to those who did not (p = 0.02). Analysis by gender showed that the mean peak VO2 in male patients who developed CVD events was significantly lower than the peak VO2 in those who did not (p < 0.03). Multiple Cox regression analysis also showed low peak VO2 to be an independent factor. In conclusion, patients with type 2 diabetes mellitus with reduced peak VO2 during exercise have a greater tendency to develop future CVD events.