Total daily sleep duration and the risk of dementia: a prospective population-based study
Total daily sleep duration and the risk of dementia: a prospective population-based study
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DOI：
10.1111/j.1468-1331.2009.02618.x
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发表时间：
2009-09-01
影响因子：
5.1
通讯作者：
Louis, E. D.
中科院分区：
文献类型：
--
作者：
Benito-Leon, J.;Bermejo-Pareja, F.;Louis, E. D.
背景和目的：我们在一项基于人群的研究中确定了睡眠时间是否与痴呆风险增加有关。方法：在西班牙中部的一项基于人群的研究中，参与者在基线和3年后进行评估。基线人口统计变量被记录下来，参与者表示他们每天的睡眠时间是夜间睡眠和白天小睡的总和。平均每日总睡眠时间分为五类：< 5小时（短睡眠者）、6小时、7小时（参考）、8小时和>= 9小时（长睡眠者）。我们确定了所有使用DSM-IV标准诊断的偶发性痴呆病例。结果：三千二千八十六名参与者有关于睡眠时间的基线信息，随访时间中位数为3.2年。有140例痴呆病例。短睡眠者和长睡眠者的相对危险度（RR）分别为2.36 （95% CI = 1.07-5.21, P = 0.03）和2.40 （95% CI = 1.20-4.81, P = 0.01）。调整潜在混杂因素后，短睡眠者的RR仅略有增加（1.87,95% CI = 0.85-4.15, P = 0.12），但长睡眠者的RR仍然增加（2.18,95% CI = 1.09-4.37, P = 0.03）。结论：睡眠时间延长（夜间睡眠和白天午睡）可能与痴呆风险增加有关。
Background and purpose:We determined in a population-based study whether sleep duration was associated with an increased risk of incident dementia.Methods:In a population-based study in central Spain, participants were evaluated at baseline and 3 years later. Baseline demographic variables were recorded and participants indicated their daily sleep duration as the sum of night-time sleep and daytime napping. The average daily total sleep duration was grouped into five categories: < 5 (short sleepers), 6, 7 (reference), 8, and >= 9 h (long sleepers). We identified all cases with incident dementia, diagnosed using DSM-IV criteria.Results:Three thousand two hundred eighty six participants with baseline information about sleep duration had a median duration of follow-up of 3.2 years. There were 140 incident cases of dementia. The relative risks (RR) for short sleepers and for long sleepers were 2.36 (95% CI = 1.07-5.21, P = 0.03) and 2.40 (95% CI = 1.20-4.81, P = 0.01), respectively. After adjustment for potential confounders, the RR was only marginally increased for short sleepers (1.87, 95% CI = 0.85-4.15, P = 0.12) but remained increased for long sleepers (2.18; 95% CI = 1.09-4.37, P = 0.03).Conclusions:Prolonged sleep duration (night-time sleep and daytime napping) may be associated with an increased risk of dementia.