Cancer mortality following cardiac catheterization: a preliminary follow-up study on 4,891 irradiated children.
Cancer mortality following cardiac catheterization: a preliminary follow-up study on 4,891 irradiated children.
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心导管插入术后的癌症死亡率：对 4,891 名受辐射儿童的初步随访研究。
DOI：
10.1542/peds.71.2.235
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发表时间：
1983
期刊：
影响因子：
8
通讯作者：
A. Newman
中科院分区：
文献类型：
--
作者：
R. Spengler;D. Cook;E. Clarke;P. Olley;A. Newman
对心导管术后放射诱发癌症死亡的风险进行了一项回顾性队列研究。这项研究包括1946年至1968年在多伦多患病儿童医院接受心导管检查的4891名先天性心脏病儿童。该队列与1950年至1975年安大略省癌症死亡文件进行了匹配。平均随访期为13年，从队列中积累了66,000多人年。没有发现死于乳腺癌或甲状腺癌的病例。观察了5例癌症死亡病例，并与基于安大略省癌症死亡率的4.8例预期死亡病例进行了比较。这5例癌症死亡是由3例白血病、1例肾母细胞瘤和1例未指明的神经系统肿瘤引起的。初步研究结果并未显示诊断性心导管置入术存在明显的白血病风险。需要对这一队列进行持续跟踪，以评估乳腺癌和甲状腺癌的风险，这些癌症可能在辐射暴露后20多年发生。
A retrospective cohort study was conducted on the risk of radiation-induced cancer mortality following cardiac catheterization. The study included 4,891 children with congenital heart disease who were assessed by cardiac catheterization during 1946 to 1968 at The Hospital for Sick Children, Toronto. The cohort was matched against the Ontario cancer death file from 1950 to 1975. The average period of follow-up was 13 years and more than 66,000 person-years have been accrued from the cohort. No deaths from breast cancer or thyroid cancer were identified. Five cancer deaths were observed and compared with 4.8 expected deaths based on Ontario cancer death rates. The five cancer deaths resulted from three leukemias, one Wilms' tumor, and one unspecified nervous system tumor. The preliminary findings did not demonstrate a significant leukemia risk arising from diagnostic cardiac catheterizations. Continued follow-up of this cohort is required to evaluate the risk of breast and thyroid cancers which can occur more than 20 years following radiation exposure.