The association between alcohol consumption and prevalent cardiovascular diseases among HIV-infected and HIV-uninfected men.
The association between alcohol consumption and prevalent cardiovascular diseases among HIV-infected and HIV-uninfected men.
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DOI：
10.1097/qai.0b013e3181c6c4b7
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
VACS Project Team
中科院分区：
文献类型：
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作者：
Freiberg MS;McGinnis KA;Kraemer K;Samet JH;Conigliaro J;Curtis Ellison R;Bryant K;Kuller LH;Justice AC;VACS Project Team
为了确定感染 HIV 的退伍军人中饮酒是否与心血管疾病 (CVD) 相关，我们使用既定的饮酒阈值，分析了来自退伍军人衰老队列研究的 4743 名男性（51% HIV 感染者）的横断面数据，该研究是一个前瞻性队列，由 HIV 感染者和人口统计相似的未感染退伍军人组成。使用逻辑回归，我们估计了饮酒与流行的 CVD 之间关联的比值比 (OR)。在艾滋病毒感染者和未感染者中，危险饮酒（33.2% vs. 30.9%）、酒精滥用和依赖（20.9% vs. 26.2%）以及CVD（14.6% vs. 19.8%）很常见。在 HIV 感染男性中，与不经常饮酒和适度饮酒相比，危险饮酒（OR=1.43，95% 置信区间 (CI)=1.05-1.94）以及酒精滥用和依赖（OR=1.55，95% CI=1.07-2.23）与较高的 CVD 患病率相关。在未感染 HIV 的男性中，过去饮酒者的 CVD 患病率较高（OR=1.30，95% CI=1.01-1.67）。对于感染艾滋病毒和未感染艾滋病毒的男性来说，传统危险因素和肾脏疾病与心血管疾病相关。在 HIV 感染男性中，即使在调整了传统 CVD 危险因素、抗逆转录病毒治疗和 CD 4 计数后，与不频繁和适度饮酒相比，危险饮酒以及酒精滥用和酒精依赖与 CVD 患病率较高相关。
To determine whether alcohol consumption is associated with cardiovascular disease (CVD) among HIV infected veterans Using established thresholds for alcohol consumption, we analyzed cross-sectional data from 4743 men 51% HIV infected) from the Veterans Aging Cohort Study, a prospective cohort of HIV infected and demographically similar uninfected veterans. Using logistic regression, we estimated the odds ratio (OR) for the association between alcohol consumption and prevalent CVD. Among HIV infected and uninfected men respectively, hazardous drinking (33.2% vs. 30.9%,), alcohol abuse and dependence (20.9% vs. 26.2%), and CVD (14.6% vs. 19.8%) were common. Among HIV infected men, hazardous drinking (OR=1.43, 95% confidence interval (CI)=1.05-1.94) and alcohol abuse and dependence (OR=1.55, 95% CI=1.07-2.23) were associated with a higher prevalence of CVD compared with infrequent and moderate drinking. Among HIV uninfected men, past drinkers had a higher prevalence of CVD (OR=1.30, 95% CI=1.01-1.67). For HIV infected and uninfected men, traditional risk factors and kidney disease were associated with CVD. Among HIV infected men, hazardous drinking and alcohol abuse and dependence were associated with a higher prevalence of CVD compared with infrequent and moderate drinking even after adjusting for traditional CVD risk factors, antiretroviral therapy, and CD 4 count.