Premature Ovarian Insufficiency: An Adolescent Series
Premature Ovarian Insufficiency: An Adolescent Series
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DOI：
10.1016/j.jpag.2017.04.003
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发表时间：
2017-12-01
影响因子：
1.8
通讯作者：
Michala, Lina
中科院分区：
文献类型：
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作者：
Chaloutsou, Kallirroi;Aggelidis, Pantelis;Michala, Lina
研究目的：探讨青少年卵巢功能不全（POI）的临床表现及病因。设计图：回顾性笔记review.Set：三级转诊门诊儿科和青少年妇科。参与者：青少年与POI。干预措施：标准POI evaluation.Main结局措施：年龄和临床症状在介绍，致病因素POI，如果identified.Results：我们确定了22个女孩与POI，平均年龄为15.6岁。其中8例表现为青春期延迟，3例为原发性闭经，其余表现为不规则出血（n = 9）或继发性闭经（n = 2）。在那些青春期延迟的人中，只有3人被发现有性染色体异常。一个明确的原因，POI被确定在3个进一步cases.Conclusion：虽然POI在青少年传统上是与原发性闭经和青春期延迟，一部分的女孩会出现不规则出血，可能会被误认为是预期的青春期月经紊乱，从而延误诊断。我们在6例病例中确定了POI的明确原因。虽然没有POI的家族性病例，但遗传原因可能参与发病机制。
Study Objective: To study the presentation and causes of premature ovarian insufficiency (POI) in adolescents. Design: Retrospective notes review.Setting: Tertiary referral outpatient clinic for pediatric and adolescent gynecology.Participants: Adolescents with POI.Interventions: Standard POI evaluation.Main Outcome Measures: Age and clinical symptoms at presentation, causative factors for POI, if identified.Results: We identified 22 girls with POI, with a mean age of 15.6 years. Eight of them presented with delayed puberty, 3 with primary amenorrhea, and the remainder presented with either irregular bleeding (n = 9) or secondary amenorrhea (n = 2). For those who presented with delayed puberty, only 3 were found to have a sex chromosome abnormality. A clear cause for the POI was identified in 3 further cases.Conclusion: Although POI in adolescents traditionally is associated with primary amenorrhea and delayed puberty, a proportion of girls will present with irregular bleeding that might be mistaken for expected menstrual disturbances of puberty, thus delaying the diagnosis. We identified a clear cause for POI in 6 cases. Although there were no familial cases of POI, it remains a possibility that genetic reasons might be involved in the pathogenesis.