STRUCTURE ACTIVITY RELATIONSHIP OF THE WARBURGIA SESQUITERPENE DIALDEHYDES

STRUCTURE ACTIVITY RELATIONSHIP OF THE WARBURGIA SESQUITERPENE DIALDEHYDES
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DOI：
10.1080/00021369.1984.10866095
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发表时间：
1984-01-01
期刊：
AGRICULTURAL AND BIOLOGICAL CHEMISTRY
影响因子：
--
通讯作者：
KUBO, I
KUBO, I
中科院分区：
其他
文献类型：
--
作者：
TANIGUCHI, M;ADACHI, T;KUBO, I

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Sesquiterpene dialdehydes from East African Warburgia trees, exhibit strong antimicrobial activity. Their chemical reactivities and biological activities were investigated in comparison with those of related compounds. There was a good correlation between the antifungal activity and the papain inhibitory activity of these compounds. Both activities apparently result from their highly specific reactivity with sulfhydryl groups. Consideration of the structure-activity relationships led to the proposal of a structure unit, the enal-aldehyde moiety, that is essential to biological activity.