REDUNDANT DOMAINS CONTRIBUTE TO THE TRANSCRIPTIONAL ACTIVITY OF THE THYROID-TRANSCRIPTION-FACTOR-1
REDUNDANT DOMAINS CONTRIBUTE TO THE TRANSCRIPTIONAL ACTIVITY OF THE THYROID-TRANSCRIPTION-FACTOR-1
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DOI：
10.1074/jbc.270.44.26649
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发表时间：
1995-11-03
影响因子：
4.8
通讯作者：
DILAURO, R
中科院分区：
文献类型：
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作者：
DEFELICE, M;DAMANTE, G;DILAURO, R
甲状腺转录因子1 （TTF-1）是一种含有同源结构域的蛋白，与甲状腺特异性基因表达的激活有关。在这里，我们报道TTF-1能够激活非甲状腺细胞中甲状腺球蛋白的转录，并在较小程度上激活甲状腺过氧化物酶基因启动子的转录。TTF-1完全激活甲状腺球蛋白启动子需要至少两个TTF-1结合位点的存在。TTF-1通过两个功能冗余的转录激活域激活转录，竞争实验表明，这两个转录激活域可能使用一个共同的中介因子。
The thyroid transcription factor 1 (TTF-1) is a homeodomain-containing protein implicated in the activation of thyroid-specific gene expression. Here we report that TTF-1 is capable of activating transcription from thyroglobulin and, to a lesser extent, thyroperoxidase gene promoters in nonthyroid cells. Full transcriptional activation of the thyroglobulin promoter by TTF-1 requires the presence of at least two TTF-1 binding sites. TTF-1 activates transcription via two functionally redundant transcriptional activation domains that as suggested by competition experiments, could use a common intermediary factor.