Stimulation of sensory neurons improves cognitive function by promoting the hippocampal production of insulin-like growth factor-I in mice
Stimulation of sensory neurons improves cognitive function by promoting the hippocampal production of insulin-like growth factor-I in mice
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DOI：
10.1016/j.trsl.2009.05.001
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发表时间：
2009-08-01
影响因子：
7.8
通讯作者：
Okajima, Kenji
中科院分区：
文献类型：
--
作者：
Harada, Naoaki;Narimatsu, Noriko;Okajima, Kenji
降钙素基因相关肽（CGRP）增加小鼠大脑中胰岛素样生长因子- i （IGF-I）的产生。IGF-I通过增加突触传递和诱导海马血管生成和神经发生对认知功能产生有益影响。在目前的研究中，我们使用野生型（WT）和CGRP敲除（CGRP-/-）小鼠，研究了辣椒素刺激感觉神经元是否通过增加海马中IGF-I的产生来改善认知功能。辣椒素给药后，WT小鼠海马组织CGRP、IGF-I和IGF-I信使RNA （mRNA）水平显著升高(P
Calcitonin gene-related peptide (CGRP) increases the production of insulin-like growth factor-I (IGF-I) in the mouse brain. IGF-I exerts beneficial effects on the cognitive function by increasing synaptic transmission and by inducing angiogenesis and neurogenesis in the hippocampus. In the current study, we examined whether stimulation of sensory neurons by capsaicin improved the cognitive function by increasing the production of IGF-I in the hippocampus using wild-type (WT) and CGRP-knockout (CGRP-/-) mice.Significant increases of the hippocampal tissue levels of CGRP, IGF-I, and IGF-I messenger RNA (mRNA) were observed after capsaicin administration in WT mice (P