Increasing Prevalence of High-Level Gentamicin Resistance among Enterococci Isolated in Greece
Increasing Prevalence of High-Level Gentamicin Resistance among Enterococci Isolated in Greece
复制标题
希腊分离的肠球菌中高水平庆大霉素耐药性的患病率不断增加
DOI：
10.1159/000048505
复制
发表时间：
2001
期刊：
影响因子：
3.3
通讯作者：
A. Antoniadis
中科院分区：
文献类型：
--
作者：
A. Tsakris;S. Pournaras;A. Maniatis;J. Douboyas;A. Antoniadis
High-level gentamicin-resistant enterococci (HLGRE) (MIC >512 µg/ml) were frequently recovered in the AHEPA University Hospital, Thessaloniki, Greece, during a 15-month period (67/158, 42.4%). PCR testing showed that high-level gentamicin resistance was attributable to the presence of the aac(6′)-aph(2′′) gene, while the recently described genes aph (2′′)-Ic and aph(2′′)-Id were not detected. High-level gentamicin resistance could be transferred with varying frequency from 41 of 57 Enterococcus faecalis and 5 of 10 Enterococcus faecium isolates. All transconjugants acquired high-level resistance to streptomycin. HLGRE cause therapeutic problems in our region, since none of the clinically available aminoglycosides can be used in severe infections.
