Gene regulation by Sp1 and Sp3
Gene regulation by Sp1 and Sp3
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DOI：
10.1139/o04-045
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发表时间：
2004-08-01
影响因子：
2.9
通讯作者：
Davie, JR
中科院分区：
文献类型：
--
作者：
Li, L;He, SH;Davie, JR
Sp转录因子家族由三个保守的Cys2His2锌指结合而成，形成序列特异性DNA结合域。在Sp转录因子家族中，Sp1和Sp3在哺乳动物细胞中广泛表达。它们可以通过GC盒结合并作用于多个靶基因的基因表达。尽管Sp1和Sp3在DNA结合域上具有相似的结构和高度的同源性，但体内外研究表明，这两个转录因子具有显著不同的功能。SP1和SP3能够增强或抑制启动子活性。Sp1和Sp3转录活性的调节主要发生在翻译后水平。本文就Sp1和Sp3在基因表达调控中的作用作一综述。
The Sp family of transcription factors is united by a particular combination of three conserved Cys2His2 zinc fingers that form the sequence-specific DNA-binding domain. Within the Sp family of transcription factors, Sp1 and Sp3 are ubiquitously expressed in mammalian cells. They can bind and act through GC boxes to regulate gene expression of multiple target genes. Although Sp1 and Sp3 have similar structures and high homology in their DNA binding domains, in vitro and in vivo studies reveal that these transcription factors have strikingly different functions. Sp1 and Sp3 are able to enhance or repress promoter activity. Regulation of the transcriptional activity of Sp1 and Sp3 occurs largely at the post-translational level. In this review, we focus on the roles of Sp1 and Sp3 in the regulation of gene expression.