Medication-taking behavior in a cohort of patients with inflammatory bowel disease
Medication-taking behavior in a cohort of patients with inflammatory bowel disease
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DOI：
10.1007/s10620-006-9444-2
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发表时间：
2006-12-01
影响因子：
3.1
通讯作者：
Gassull, Miquel A.
中科院分区：
文献类型：
--
作者：
Bernal, Isabel;Domenech, Eugeni;Gassull, Miquel A.
最近的研究表明，炎症性肠病（IBD）患者维持治疗的依从率较低。我们试图评估IBD患者队列的服药行为。我们前瞻性纳入了来自门诊的IBD患者，他们同意回答关于处方治疗和依从性的问卷。医生登记临床数据，包括处方药。纳入214例患者（115例克罗恩病/99例溃疡性结肠炎）。最常用的处方药是口服美沙拉秦（56.5%）和免疫调节剂（41.1%）。43%的患者承认偶尔会忘记服药，但只有7.5%的人是自愿的。口服美沙拉秦和硫唑嘌呤是依从性最差的药物，不依从率分别为处方总剂量的45%和25%。与更好的依从性相关的唯一因素是病程更复杂-类固醇依赖、类固醇无效、需要英夫利昔单抗治疗、住院或手术（P=.02）。百分之二十的病人承认自己服药。很大一部分IBD患者承认在转诊中心的专业单位忘记了一些剂量的处方药。
Recent studies have shown a low adherence rate to maintenance treatment in patients with inflammatory bowel disease (IBD). We sought to assess the medication-taking behavior in a cohort of patients with IBD. We prospectively included IBD patients from the outpatient clinic who agreed to answer a questionnaire about prescribed treatment and adherence. Physicians registered clinical data including prescribed medications. Two hundred fourteen patients (115 Crohn's disease/99 ulcerative colitis) were included. The most prescribed medications were oral mesalazine (56.5%) and immunomodulators (41.1%). Forty-three percent of patients admitted to occasionally forgetting to take their medication but only 7.5% of them did it voluntary. Oral mesalazine and azathioprine were the drugs with the poorest compliance, with nonadherence rates of 45% and 25% of the total prescribed doses, respectively. The only factor associated with a better adherence was a more complicated course of the disease-steroid dependency, steroid refractoriness, need for infliximab treatment, hospitalization, or surgery (P=.02). Twenty percent of patients admitted to self-medicating. An important proportion of patients with IBD admit to forget some doses of the prescribed medication in the setting of a specialized unit of a referral centre.