Isolation of new carbamate- or pyridine-containing natural products, fuzanins A, B, C, and D from Kitasatospora sp IFM10917
Isolation of new carbamate- or pyridine-containing natural products, fuzanins A, B, C, and D from Kitasatospora sp IFM10917
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DOI：
10.1016/j.tet.2008.10.040
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发表时间：
2009-01-03
期刊：
影响因子：
2.1
通讯作者：
Ishibashi, Masami
中科院分区：
文献类型：
--
作者：
Aida, Wataru;Ohtsuki, Takashi;Ishibashi, Masami
从北里孢菌（Kitasatospora sp.）IFM 10917的培养上清中分离得到了新的氨基甲酸酯或吡啶类天然产物fuzanins A（1）、B（2）、C（3）和D（4）。这些化合物通过溶剂分离、柱色谱和制备HPLC连续纯化。每种化合物的化学结构都是根据光谱分析和化学方法确定的。Fuzanin D（4）显示出对DLD-1细胞的细胞毒性（IC 50，41.2 μ M）和在25 μ M时对Wnt信号转录的中度抑制。(C)2008爱思唯尔有限公司保留所有权利。
New carbamate or pyridine-containing natural products, fuzanins A (1), B (2), C (3), and D (4), were isolated from the culture supernatant of Kitasatospora sp. IFM10917. These compounds were purified by solvent separation, column chromatography, and preparative HPLC, consecutively. The chemical structure of each compound was established on the basis of a spectroscopic analysis and chemical means. Fuzanin D (4) showed cytotoxicity against DLD-1 cells (IC50, 41.2 mu M) and moderate inhibition of Wnt signal transcription at 25 mu M. (C) 2008 Elsevier Ltd. All rights reserved.