Neural correlates of category-specific knowledge
Neural correlates of category-specific knowledge
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DOI：
10.1038/379649a0
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发表时间：
1996-02-15
期刊：
影响因子：
64.8
通讯作者：
Haxby, JV
中科院分区：
文献类型：
--
作者：
Martin, A;Wiggs, CL;Haxby, JV
人类大脑损伤的一个有趣和令人困惑的后果是选择性地丧失对特定类别物体的知识，一个患者可能无法识别或命名生物（1-3），而另一个患者可能有选择性地难以识别人造物体（4-6）。为了研究这种显著分离的神经相关性，我们使用正电子发射断层扫描来绘制与命名动物和工具相关的正常大脑区域。我们发现，动物和工具的命名图片与双侧腹侧颞叶和布罗卡区的激活有关，此外，命名动物选择性激活左侧内侧枕叶-一个参与视觉加工的最早阶段的区域。相比之下，命名工具选择性地激活了左侧运动前区，也被想象的手部动作激活（7），左侧颞中回的一个区域也被动作词的产生激活（8-10）。因此，在物体识别过程中活跃的大脑区域部分取决于所呈现物体的内在属性。
AN intriguing and puzzling consequence of damage to the human brain is selective loss of knowledge about a specific category of objects, One patient may be unable to identify or name living things(1-3), whereas another may have selective difficulty identifying man-made objects(4-6). To investigate the neural correlates of this remarkable dissociation, we used positron emission tomography to map regions of the normal brain that are associated with naming animals and tools. We found that naming pictures of animals and tools was associated with bilateral activation of the ventral temporal lobes and Broca's area, In addition, naming animals selectively activated the left medial occipital lobe-a region involved in the earliest stages of visual processing. In contrast, naming tools selectively activated a left premotor area also activated by imagined hand movements(7), and an area in the left middle temporal gyrus also activated by the generation of action words(8-10). Thus the brain regions active during object identification are dependent, in part, on the intrinsic properties of the object presented.