Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period
Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period
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DOI：
10.1038/sj.ejhg.5200859
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发表时间：
2002-11-01
影响因子：
5.2
通讯作者：
Edvinsson, S
中科院分区：
文献类型：
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作者：
Kaati, G;Bygren, LO;Edvinsson, S
家庭中的过度喂养和暴饮暴食是经常代代相传的传统。不管这些家庭传统如何，食物供应可能会导致过度喂养，进而导致新陈代谢适应。除了选择，这些对社会环境的适应是否会产生代际效应？这项研究将试图回答以下问题：在儿童生长速度达到青春期前高峰之前的缓慢生长期（SGP）暴饮暴食是否会影响后代死于心血管疾病和糖尿病的风险？数据收集了以下三个队列出生于1890年，1905年和1920年在瑞典北方的Overkalix教区，直到死亡或1995年。父母或祖父母在政治革新方案期间获得食物的情况是参照有关收成和粮食价格的历史数据、当地社区会议记录和一般历史事实确定的。如果在父亲生长缓慢期间食物不容易获得，则先证者的心血管疾病死亡率较低。糖尿病死亡率增加，如果父亲的祖父暴露于过量的食物在他的缓慢增长期间。(Odds比值4.1，95%置信区间1.33-12.93，P=0.01）。选择偏差似乎不太可能。通过雄性系的营养相关机制似乎影响了心血管和糖尿病死亡率的风险。
Overfeeding and overeating in families are traditions that are often transferred from generation to generation. Irrespective of these family traditions, food availability might lead to overfeeding, in its turn leading to metabolic adaptations. Apart from selection, could these adaptations to the social environment have transgenerational effects? This study will attempt to answer the following question: Can overeating during a child's slow growth period (SGP), before their prepubertal peak in growth velocity influence descendants' risk of death from cardiovascular disease and diabetes? Data were collected by following three cohorts born in 1890, 1905 and 1920 in Overkalix parish in northern Sweden up until death or 1995. The parents' or grandparents' access to food during their SGP was determined by referring to historical data on harvests and food prices, records of local community meetings and general historical facts. If food was not readily available during the father's slow growth period, then cardiovascular disease mortality of the proband was low. Diabetes mortality increased if the paternal grandfather was exposed to a surfeit of food during his slow growth period. (Odds Ratio 4.1, 95% confidence interval 1.33-12.93, P=0.01). Selection bias seemed to be unlikely. A nutrition-linked mechanism through the male line seems to have influenced the risk for cardiovascular and diabetes mellitus mortality.