Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance.
Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance.
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抑制生长素释放肽会加剧 HFCS 引起的肥胖和胰岛素抵抗
DOI：
10.3390/ijms18061302
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发表时间：
2017-06-19
影响因子：
5.6
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Ma X;Lin L;Yue J;Wu CS;Guo CA;Wang R;Yu KJ;Devaraj S;Murano P;Chen Z;Sun Y
在美国，高果糖玉米糖浆（HFCS）被广泛用作加工食品和软饮料中的甜味剂，主要取代蔗糖（SUC）。促食欲激素ghrelin促进肥胖和胰岛素抵抗; ghrelin对HFCS和SUC摄入的反应不同。在这里，我们研究了ghrelin在HFCS和SUC诱导的肥胖和胰岛素抵抗中的作用。为了模仿软饮料，10周龄的雄性野生型（WT）和Ghrelin敲除（Ghrelin−/−）小鼠被随意给予。补充有水（RD）、8%HFCS（HFCS）或10%蔗糖（SUC）的常规食物饮食。我们发现，SUC喂养诱导更强大的增加体重和体脂比HFCS-feeding。与SUC喂养的小鼠相比，HFCs喂养的小鼠体重较低，但循环葡萄糖和胰岛素水平较高。有趣的是，我们还发现ghrelin缺失会加剧HFCs诱导的脂肪组织肥胖和炎症，以及全身胰岛素抵抗。我们的研究结果表明，HFCS和SUC对脂质代谢有不同的影响：而蔗糖促进肥胖，HFCS主要增强炎症和胰岛素抵抗，ghrelin赋予这些代谢功能障碍的保护作用。
High fructose corn syrup (HFCS) is widely used as sweetener in processed foods and soft drinks in the United States, largely substituting sucrose (SUC). The orexigenic hormone ghrelin promotes obesity and insulin resistance; ghrelin responds differently to HFCS and SUC ingestion. Here we investigated the roles of ghrelin in HFCS- and SUC-induced adiposity and insulin resistance. To mimic soft drinks, 10-week-old male wild-type (WT) and ghrelin knockout (Ghrelin−/−) mice were subjected to ad lib. regular chow diet supplemented with either water (RD), 8% HFCS (HFCS), or 10% sucrose (SUC). We found that SUC-feeding induced more robust increases in body weight and body fat than HFCS-feeding. Comparing to SUC-fed mice, HFCS-fed mice showed lower body weight but higher circulating glucose and insulin levels. Interestingly, we also found that ghrelin deletion exacerbates HFCS-induced adiposity and inflammation in adipose tissues, as well as whole-body insulin resistance. Our findings suggest that HFCS and SUC have differential effects on lipid metabolism: while sucrose promotes obesogenesis, HFCS primarily enhances inflammation and insulin resistance, and ghrelin confers protective effects for these metabolic dysfunctions.