HYPOZINCEMIA IN DEPRESSION
HYPOZINCEMIA IN DEPRESSION
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DOI：
10.1016/0165-0327(94)90117-1
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发表时间：
1994-06-01
影响因子：
6.6
通讯作者：
DEBROE, ME
中科院分区：
文献类型：
--
作者：
MAES, M;DHAESE, PC;DEBROE, ME
本研究调查了48例单极抑郁症患者（轻度16例，单纯重度14例，忧郁症18例）和32例正常人血清锌水平，以及锌血症与血浆新嘌呤水平、地塞米松后促肾上腺皮质激素和皮质醇值、厌食症-体重减轻之间的关系。重度抑郁症患者的血清锌水平明显低于正常对照组，而轻度抑郁症患者的血清锌水平则处于中间水平。血清锌、抑郁严重程度和血浆新蝶呤浓度呈显著负相关。锌血症与地塞米松后激素值或厌食症/体重减轻之间没有显著关系。研究结果表明，重度抑郁症患者的低锌血症可能与该疾病中细胞介导的免疫激活有关。
This study investigates serum levels of zinc in 48 unipolar depressed subjects (16 minor, 14 simple major and 18 melancholic subjects) and 32 normal volunteers, and the relationships between zincemia and plasma neopterin levels, postdexamethasone adrenocorticotropic hormone and cortisol values, and anorexia-weight loss. Serum zinc levels were significantly lower in major depressed subjects than in normal controls, whereas minor depressed subjects showed intermediate values. There were significant negative correlations between serum zinc, and severity of depression and plasma neopterin concentrations. No significant relationships between zincemia and either postdexamethasone hormone values or anorexia/weight loss were found. The findings suggest that hypozincemia in major depression may be related to activation of cell-mediated immunity in that illness.