Drug-induced supersensitivity psychosis revisited: characteristics of relapse in treatment-compliant patients
Drug-induced supersensitivity psychosis revisited: characteristics of relapse in treatment-compliant patients
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DOI：
10.1177/2045125311431105
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发表时间：
2012-02-01
影响因子：
4.2
通讯作者：
Deakin, Bill
中科院分区：
文献类型：
--
作者：
Fallon, Paul;Dursun, Serdar;Deakin, Bill
背景资料：既往在一组依从抗精神病药物治疗的患者中报告了异常不自主运动与精神病复发之间的相关性（Fallon and Dursun 2011）。这被解释为存在的抗精神病药物引起的超敏性psycho.Method：从该研究的结果和Chouinard诊断标准的超敏性精神病的一个简短的诊断检查表，以确定的现象。在本研究中，使用的检查表上的药物依从性的个人经历了一个精神病reactivity.Results：该检查表证明了其效用，通过确定复发的原因，在70%（29/41）的患者。此外，它确定了39%（16/41）的患者存在超敏性精神病。这项研究还复制了一些研究结果，从以前的文件支持的想法，超敏性精神病是一个原因的复发psychiatris.Discussion：这些结果表明，临床医生应谨慎处方，并可能要增加治疗与其他药物或切换到低多巴胺亲和力抗精神病药物。
Background: An association between abnormal involuntary movements and psychotic relapse was previously reported in a group of patients compliant with antipsychotic medication (Fallon and Dursun 2011). This was interpreted as the presence of an antipsychotic medication-induced supersensitivity psychosis.Method: From the results of that study and the Chouinard diagnostic criteria for supersensitivity psychosis an abbreviated diagnostic checklist was developed to identify the phenomenon. In the present study the checklist was used on a larger sample of medication-compliant individuals experiencing a psychotic relapse.Results: The checklist demonstrated its utility by identifying a cause of relapse in 70% (29/41) of patients. Furthermore, it identified the presence of supersensitivity psychosis in 39% (16/41) of patients. This study also replicated a number of findings from the previous paper supporting the idea that supersensitivity psychosis is one cause of relapse in psychosis.Discussion: These results suggested that clinicians should exercise caution in prescribing and may have to augment treatment with other agents or switch to low dopamine-affinity antipsychotics.