Capsaicin and nociception.
Capsaicin and nociception.
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辣椒素和伤害感受。
DOI：
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发表时间：
1987
影响因子：
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通讯作者：
J. Szolcsányi
中科院分区：
文献类型：
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作者：
J. Szolcsányi
辣椒素对有害化学刺激的抗伤害性作用已被证实。然而，对于热或机械伤害性感受，常规药理学方法的结果相互矛盾。因此，使用新的技术，不同的刺激的伤害性阈值测定大鼠的后爪。全身给药（400 mg/kg s.c.）后，神经周（坐骨神经上1%）和局部（后爪中5微克）应用辣椒素，有害热的阈值（47.4 +/-0.08）分别向上移动3.3 ℃、4.1 ℃和2.9 ℃。针刺（186 +/- 9 mN力）诱发的机械伤害性阈值变化更多变。对经皮二甲苯应用的反应被消除或明显抑制。全身应用后，对有毒热的反应性恢复快于二甲苯的作用。从大鼠隐神经分离的C-多模态伤害感受器和一些A-δ机械热敏伤害感受器被近动脉给予的纳克剂量的辣椒素激活。5微克辣椒素在长时间潜伏期后刺激了少数缓慢适应的A机械感受器，但没有A-δ机械感受器或其他皮肤感受器。全身治疗后，C-多模态伤害性感受器的比例降低，C-机械感受器的比例增加。强调多通道型伤害感受器的作用，其他伤害感受器的相互作用，以及继发性的动态变化来解释辣椒素的抗伤害效应。
The antinociceptive effect of capsaicin to noxious chemical stimuli has been invariably verified. As to thermal or mechanical nociception, however, routine pharmacological methods resulted in conflicting findings. Therefore, using new techniques the nociceptive thresholds of different stimuli were determined on the hindpaw of the rat. After systemic (400 mg/kg s.c.), perineural (1% on the sciatic nerve) and local (5 micrograms into the hindpaw) application of capsaicin the threshold for noxious heat (47.4 +/- 0.08) was shifted upwards by 3.3 degrees C, 4.1 degrees C and 2.9 degrees C, respectively. The changes in mechanonociceptive threshold evoked by pin prick (186 +/- 9 mN force) were more variable. The response to percutaneous xylene application was abolished or markedly inhibited. After systemic application the responsiveness to noxious heat recovered faster than the effect of xylene. C-polymodal nociceptors and some A-delta mechanoheat-sensitive nociceptors isolated from the saphenous nerve of the rat were activated by capsaicin in nanogram doses given close arterially. Five micrograms capsaicin excited few slowly adapting A mechanoreceptors after a long latency, but not A-delta mechanonociceptors or other cutaneous receptors. Proportion of C-polymodal nociceptors was decreased, that of the C-mechanoreceptors was increased after systemic treatment. The role of polymodal-type nociceptors, interaction of other nociceptors, as well as secondary dynamic changes are stressed to explain the antinociceptive effect of capsaicin.