HYPERTHERMIA-INDUCED DAMAGE TO RAT SCIATIC-NERVE ASSESSED INVIVO WITH FUNCTIONAL METHODS AND WITH ELECTROPHYSIOLOGY
HYPERTHERMIA-INDUCED DAMAGE TO RAT SCIATIC-NERVE ASSESSED INVIVO WITH FUNCTIONAL METHODS AND WITH ELECTROPHYSIOLOGY
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DOI：
10.1016/0165-0270(92)90073-m
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发表时间：
1992-12-01
影响因子：
3
通讯作者：
HAVEMAN, J
中科院分区：
文献类型：
--
作者：
DEVRIND, HH;WONDERGEM, J;HAVEMAN, J
用黄铜热模对大鼠坐骨神经5mm段进行不同时间的体内热疗（43-45℃）。这种局部热处理对神经的影响通过电生理学和两种功能分析来评估。热疗导致运动和感觉功能的剂量依赖性下降。电生理检查显示运动和反射反应幅度下降，而非传导速度下降。两种功能方法和电生理方法计算的ED50值无显著差异。所有病例均能从神经损伤中恢复功能。在相同的损伤水平下，即50%功能丧失，完全感觉功能丧失需要14天恢复，完全运动功能丧失需要20天恢复。虽然运动和感觉功能都恢复了，但高温后30天电生理学没有检测到任何反应，这是由于恢复后髓鞘变薄的结果。
A 5-mm segment of the rat sciatic nerve was treated in vivo with hyperthermia (43-45-degrees-C) for different times using a brass thermode. The effect of this local heat treatment on the nerve was assessed with electrophysiology and using two functional assays. Hyperthermia led to a dose-dependent decrease of motor and sensory function. Electrophysiological examination showed a decrease in amplitude of motor and reflex responses rather than a decrease in conduction velocities. Calculated ED50 values were not significantly different for the two functional and for the electrophysiological methods. Functional recovery from nerve damage took place in all cases. Measured at the same level of damage, i.e., 50% function loss, it took 14 days to recover from complete sensory function loss and 20 days from complete motor function loss. Although both motor and sensory functions were restored, 30 days after hyperthermia no responses could be detected with electrophysiology, this as a result of the thin myelin sheaths that occur upon recovery.