A nonrandomized cohort and a randomized study of local control of large hepatocarcinoma by targeting intratumoral lactic acidosis
A nonrandomized cohort and a randomized study of local control of large hepatocarcinoma by targeting intratumoral lactic acidosis
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通过针对瘤内乳酸酸中毒局部控制大肝癌的非随机队列和随机研究
DOI：
10.7754/elife.15691
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发表时间：
2016-08-02
期刊：
影响因子：
7.7
通讯作者：
Hu, Xun
中科院分区：
文献类型：
--
作者：
Chao, Ming;Wu, Hao;Hu, Xun
研究设计：先前的研究表明，中和瘤内乳酸酸中毒联合葡萄糖剥夺可能是控制肿瘤的有效途径。我们进行了一项试点临床研究，包括一项非随机研究（57例大型HCC患者）和一项随机对照研究（20例大型HCC患者）。方法：采用经动脉化疗栓塞术（TACE），局部输注碳酸氢盐或不输注碳酸氢盐。结果：在非随机对照研究中，含有碳酸氢盐的TACE组活肿瘤残留物（VTR）的几何平均值比不含碳酸氢盐的TACE组低6.4倍(7.1% [95% CI: 4.6%-10.9%] vs 45.6% [28.9%-72.0%]
Study design: Previous works suggested that neutralizing intratumoral lactic acidosis combined with glucose deprivation may deliver an effective approach to control tumor. We did a pilot clinical investigation, including a nonrandomized (57 patients with large HCC) and a randomized controlled (20 patients with large HCC) studies. Methods: The patients were treated with transarterial chemoembolization (TACE) with or without bicarbonate local infusion into tumor. Results: In the nonrandomized controlled study, geometric mean of viable tumor residues (VTR) in TACE with bicarbonate was 6.4-fold lower than that in TACE without bicarbonate (7.1% [95% CI: 4.6%-10.9%] vs 45.6% [28.9%-72.0%]; p