HMGA2: A biomarker significantly overexpressed in high-grade ovarian serous carcinoma
HMGA2: A biomarker significantly overexpressed in high-grade ovarian serous carcinoma
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HMGA2：在高级别卵巢浆液性癌中显着过度表达的生物标志物
DOI：
10.1038/modpathol.2010.49
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发表时间：
2010-05-01
期刊：
影响因子：
7.5
通讯作者：
Wei, Jian-Jun
中科院分区：
文献类型：
--
作者：
Mahajan, Aparna;Liu, Zhaojian;Wei, Jian-Jun
Ovarian carcinoma consists of a group of histologically heterogeneous diseases involving distinct tumorigenic pathways.卵巢高级别乳头状浆液性癌通常与 p53 突变相关。 HMGA2 是一种癌胚蛋白，被发现在卵巢癌中过度表达。为了研究 HMGA2 在卵巢癌中的功能，了解哪些卵巢癌亚型与 HMGA2 过度表达相关非常重要。在这项研究中，我们收集了六种不同类型的卵巢癌，并通过免疫组织化学检查了 HMGA2 以及 HMGA1、p53 和 Ki-67 的表达。 We found that HMGA2 overexpression was significantly higher in high-grade papillary serous carcinoma (64%) and carcinosarcoma (60%) than in other types of ovarian cancers (7-23%). HMGA2 过表达与显性 p53 突变中度相关 (R = 0.51)。此外，microRNA原位分析显示，HMGA2阴性调节因子let-7b在高级别浆液性癌中显着丢失。我们的研究结果表明，HMGA2 是与高级别乳头状浆液性癌显着相关的重要分子变化，并且在其他组织学类型的卵巢癌中较少见。现代病理学(2010) 23, 673-681; doi：10.1038/modpathol.2010.49； 2010 年 3 月 12 日在线发布
Ovarian carcinoma consists of a group of histologically heterogeneous diseases involving distinct tumorigenic pathways. High-grade papillary serous carcinoma of the ovary is commonly associated with p53 mutations. HMGA2, an oncofetal protein, is found to be overexpressed in ovarian cancer. To study the function of HMGA2 in ovarian cancer, it is important to know which subtypes of ovarian cancer are associated with HMGA2 overexpression. In this study, we collected six different types of ovarian cancer and examined HMGA2 expression by immunohistochemistry, along with HMGA1, p53 and Ki-67. We found that HMGA2 overexpression was significantly higher in high-grade papillary serous carcinoma (64%) and carcinosarcoma (60%) than in other types of ovarian cancers (7-23%). HMGA2 overexpression was moderately associated with dominant p53 mutations (R = 0.51). In addition, the microRNA in situ analysis revealed that let-7b, the HMGA2-negative regulators, were significantly lost in high-grade serous carcinoma. Our findings suggest that HMGA2 is an important molecular change significantly related to high-grade papillary serous carcinoma and is less common in other histological types of ovarian cancer. Modern Pathology (2010) 23, 673-681; doi: 10.1038/modpathol.2010.49; published online 12 March 2010