The effects of social learning on the acquisition of cocaine self-administration
The effects of social learning on the acquisition of cocaine self-administration
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DOI：
10.1016/j.drugalcdep.2014.04.025
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发表时间：
2014-08-01
影响因子：
4.2
通讯作者：
Strickland, Justin C.
中科院分区：
文献类型：
--
作者：
Smith, Mark A.;Lacy, Ryan T.;Strickland, Justin C.
背景：物质使用的社会学习模型提出，药物使用行为是通过观察和模仿他人的行为来学习的。本研究的目的是检查三组实验幼稚大鼠中可卡因自我给药的获得：在隔离中测试的大鼠、在另一只能够获得可卡因且先前已接受过自我给药可卡因训练的大鼠存在下测试的大鼠以及在另一只不能获得可卡因的大鼠存在下测试的大鼠。雄性大鼠在隔离或成对饲养条件下饲养，并植入静脉导管。然后将成对饲养的大鼠分配至药物经验或药物初治条件。在药物经验的条件下，每对大鼠中的一只在重新引入其伴侣之前被训练独自服用可卡因。在未使用过药物的情况下，每对大鼠中的一只在研究期间无法获得可卡因。对于每个组，收购可卡因自我管理超过15天的大鼠与可卡因的访问，但没有事先operant training.Results：与药物经验丰富的合作伙伴测试的大鼠更快地获得可卡因自我管理，并发出更多的积极杠杆压力比测试与可卡因天真的合作伙伴的大鼠。隔离对照组的数据下降之间的其他两个groups on these measurements.Conclusion：这些数据表明，收购可卡因自我管理可以促进或抑制社会接触。总的来说，这些结果支持物质使用的社会学习模型。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Background: Social learning models of substance use propose that drug-use behaviors are learned by observing and mimicking the behavior of others. The aim of this study was to examine the acquisition of cocaine self-administration in three groups of experimentally naive rats: rats that were tested in isolation, rats that were tested in the presence of another rat that had access to cocaine and had previously been trained to self-administer cocaine, and rats that were tested in the presence of another rat that did not have access to cocaine.Methods: Male rats were reared in isolated or pair-housed conditions and implanted with intravenous catheters. Pair-housed rats were then assigned to drug-experienced or drug-naive conditions. In the drug-experienced condition, one rat of each pair was trained to self-administer cocaine in isolation before the reintroduction of its partner. In the drug-naive condition, one rat of each pair did not have access to cocaine for the duration of the study. For each group, the acquisition of cocaine self-administration was measured over 15 days in rats with access to cocaine but no prior operant training.Results: Rats tested with a drug-experienced partner were faster to acquire cocaine self-administration and emitted more active lever presses than rats tested with a cocaine-naive partner. Data for the isolated control group fell between the other two groups on these measures.Conclusion: These data indicate that the acquisition of cocaine self-administration can either be facilitated or inhibited by social contact. Collectively, these results support a social learning model of substance use. (C) 2014 Elsevier Ireland Ltd. All rights reserved.