Visceral Pleura Invasion Impact on Non-small Cell Lung Cancer Patient Survival Its Implications for the Forthcoming TNM Staging Based on a Large-Scale Nation-Wide Database
Visceral Pleura Invasion Impact on Non-small Cell Lung Cancer Patient Survival Its Implications for the Forthcoming TNM Staging Based on a Large-Scale Nation-Wide Database
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DOI：
10.1097/jto.0b013e3181a85d5e
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发表时间：
2009-08-01
影响因子：
20.4
通讯作者：
Miyaoka, Etsuo
中科院分区：
文献类型：
--
作者：
Yoshida, Junji;Nagai, Kanji;Miyaoka, Etsuo
简介：尚未报道与国际肺癌研究协会建议的第7版国际抗癌联合会分期系统的肿瘤、淋巴结、转移（TNM）分类有关的内脏胸膜侵犯（VPI）对分期的影响的分析。本研究的目的是评估VPI对生存的影响，并提出了一种方法，将VPI状态TNM classification.Methods：我们回顾了9758例非小细胞肺癌患者，谁在1990年进行解剖手术切除，积累了日本联合委员会肺癌登记，深入了解他们的临床病理特征和结果的数据。VPI定义为肿瘤延伸超过脏层胸膜的弹性层。根据VPI状态和肿瘤直径将患者分为9组，符合国际肺癌研究协会的建议。
Introduction: No analyses have been reported on the impact of visceral Pleura invasion (VPI) on staging, in relation with the International Association for the Study of Lung Cancer proposals for the 7th edition of the tumor, node, metastasis (TNM) classification of the International Union Against Cancer staging system. The purpose of this study was to evaluate the impact of VPI on survival and propose a method of incorporating VPI status into the TNM classification.Methods: We reviewed the data on 9758 non-small cell lung cancer patients, who underwent anatomic surgical resection in 1990, accumulated by the Japanese Joint Committee for Lung Cancer Registration, to gain insight into their clinicopathologic characteristics and Outcomes. VPI was defined as tumor extension beyond the elastic layer of the visceral pleura. Patients were divided into nine groups according to VPI status and tumor diameter, in accordance with the International Association for the Study of Lung Cancer proposals.Results: On the basis of survival, the nine groups were divided into the following five levels: tumors