Glutamate receptors form hot spots on apical dendrites of neocortical pyramidal neurons
Glutamate receptors form hot spots on apical dendrites of neocortical pyramidal neurons
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DOI：
10.1152/jn.2001.86.3.1412
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发表时间：
2001-09-01
影响因子：
2.5
通讯作者：
Dodt, HU
中科院分区：
文献类型：
--
作者：
Frick, A;Zieglgänsberger, W;Dodt, HU
第五层皮质锥体神经元的顶树突是来自皮质和皮质下脑区的谷氨酸能突触输入的主要靶点。由于来自这些区域的神经支配在树突上呈一定的层状分布，了解谷氨酸受体在顶树突上的分布对于理解新皮质中神经回路的功能至关重要。为了研究这一问题，我们使用红外引导激光刺激结合全细胞记录来量化谷氨酸受体沿第五层锥体神经元顶树突的空间分布。局部施加（
Apical dendrites of layer V cortical pyramidal neurons are a major target for glutamatergic synaptic inputs from cortical and subcortical brain regions. Because innervation from these regions is somewhat laminar along the dendrites, knowing the distribution of glutamate receptors on the apical dendrites is of prime importance for understanding the function of neural circuits in the neocortex. To examine this issue, we used infrared-guided laser stimulation combined with whole cell recordings to quantify the spatial distribution of glutamate receptors along the apical dendrites of layer V pyramidal neurons. Focally applied (