Just Antimicrobial is not Enough: Toward Bifunctional Polymer Surfaces with Dual Antimicrobial and Protein-Repellent Functionality
Just Antimicrobial is not Enough: Toward Bifunctional Polymer Surfaces with Dual Antimicrobial and Protein-Repellent Functionality
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DOI：
10.1002/macp.201500266
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发表时间：
2016-01-01
影响因子：
2.5
通讯作者：
Lienkamp, Karen
中科院分区：
文献类型：
--
作者：
Hartleb, Wibke;Saar, Julia S.;Lienkamp, Karen
抗微生物聚合物表面经常失效，因为被杀死的细菌的碎片积聚在涂层上，然后被覆盖并失活。为了克服这一缺陷，开发了两种将聚阳离子抗微生物聚合物与聚两性离子蛋白质排斥性聚合物组合的联合收割机合成方法。在第一种方法中，这些聚合物被选择性地固定在具有化学对比度的表面上，该化学对比度通过胶体光刻获得。在第二种方法中，将聚两性离子的薄冠接枝到聚阳离子抗微生物聚合物的地毯上。我们实验室最近获得的结果表明，精确控制表面结构和几何形状可以获得所需的双重功能。
Antimicrobial polymer surfaces often fail because debris of killed bacteria accumulates on the coating, which is then covered and deactivated. To overcome this deficiency, two synthetic approaches are developed that combine polycationic antimicrobial polymers with polyzwitterionic protein-repellent polymers. In the first approach, these polymers are site-selectively immobilized on surfaces with a chemical contrast, which is obtained by colloidal lithography. In the second approach, a thin corona of polyzwitterions is grafted onto a carpet of polycationic antimicrobial polymers. Results recently obtained in our laboratory suggest that precisely controlling the surface architecture and geometry can lead to the desired dual functionality.