Inhibition of metabolic cooperation in Chinese hamster V79 cells in culture by various polybrominated biphenyl (PBB) congeners.
Inhibition of metabolic cooperation in Chinese hamster V79 cells in culture by various polybrominated biphenyl (PBB) congeners.
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各种多溴联苯 (PBB) 同系物对培养的中国仓鼠 V79 细胞代谢协同的抑制。
DOI：
10.1093/carcin/3.2.181
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发表时间：
1982
期刊：
影响因子：
4.7
通讯作者：
Aust,SD
中科院分区：
文献类型：
--
作者：
Tsushimoto,G;Trosko,JE;Chang,CC;Aust,SD
使用体外分析系统测量中国仓鼠V79细胞中的一种细胞间通讯形式，分析了几种纯化的多溴联苯（PBB）同系物影响这些细胞中集落形成能力和“代谢合作”的能力。结果清楚地表明，该检测方法的能力，以区分这些同源物的细胞毒性和代谢合作抑制特性的差异与其结构。看来，如果每个苯环桥碳的邻位碳被溴化，则该分子具有抑制代谢合作的性质。结果表明，几种多溴联苯同源物至少有一种与几种已知的肿瘤促进剂（如佛波醇酯）有关的特性。虽然我们没有排除多溴联苯同源物混合物中可能含有引发剂，或者各种多溴联苯代谢物可能是诱变剂/引发剂，但根据这些结果和其他结果得出的结论是，所报告的多溴联苯的致癌潜力似乎是由其作为肿瘤促进剂的作用介导的，而不是作为一种完全的致癌物或引发剂。
Using anin vitroassay system to measure a form of cell-cell communication in Chinese hamster V79 cells, several purified polybrominated biphenyl (PBB) congeners were analyzed for their ability to affect colony-forming ability and “metabolic cooperation” in these cells. Results clearly demonstrate the assay's ability to distinguish differences in the cytotoxic and metabolic cooperation-inhibiting properties of these congeners related to their structure. It appears that if a carbonorthoto the bridge carbon of each phenyl ring is brominated, the molecule has the property by which metabolic cooperation is inhibited. The results suggest that several PBB congeners share at least one property associated with several known tumor promoters, such as the phorbol esters. Although we have not ruled out that the mixture of PBB congeners might contain initiators or that various PBB metabolites would be mutagen/initiators, based on these and other results, it was concluded that the reported carcinogenic potential of PBB seems to be mediated by its action as a tumor promoter, rather than as a complete carcinogen or an initiator.