A novel role for thioredoxin reductase in the iron metabolism of S. cerevisiae.
A novel role for thioredoxin reductase in the iron metabolism of S. cerevisiae.
复制标题
硫氧还蛋白还原酶在酿酒酵母铁代谢中的新作用。
DOI：
10.1016/j.bbrc.2008.03.156
复制
发表时间：
2008
影响因子：
3.1
通讯作者：
C. Yun
中科院分区：
文献类型：
--
作者：
Hyun;So;Dong;Mi;H. Sung;C. Yun
细胞内的铁水平受到严格的调节。酿酒酵母使用明确的途径从环境中提取铁分子。一旦进入细胞，铁分子必须通过细胞内铁转运蛋白转移到靶位点。虽然类似的载体已被描述为其他金属，如铜，铁转运蛋白尚未确定。我们利用双向凝胶电泳和质谱技术，试图从S.啤酒。在这项研究中，我们鉴定了硫氧还蛋白还原酶的铁结合活性，我们的数据表明该酶在细胞内铁转运中具有潜在作用。
Intracellular levels of iron are tightly regulated. Saccharomyces cerevisiae uses well-defined pathways to extract iron molecules from the environment. Once inside the cell, the iron molecules must be transferred to target sites via an intracellular iron transporter. Although analogous carriers have been described for other metals, such as copper, an iron transporter has yet to be identified. We used two-dimensional gel electrophoresis and mass spectrometry techniques to attempt to identify the iron transporter from cytosolic fraction of S. cerevisiae. In this study, we identified the iron-binding activity of thioredoxin reductase, and our data suggest a potential role for this enzyme in intracellular iron transport.
影响因子：
7.4
作者：
Hansen, JM;Zhang, H;Jones, DP
通讯作者：
Jones, DP
影响因子：
4.1
作者：
Ding, HG;Clark, RJ
通讯作者：
Clark, RJ