Recent Advances in Folates and Autoantibodies against Folate Receptors in Early Pregnancy and Miscarriage.
Recent Advances in Folates and Autoantibodies against Folate Receptors in Early Pregnancy and Miscarriage.
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叶酸以及妊娠早期和流产中针对叶酸受体的自身抗体的最新研究进展
DOI：
10.3390/nu15234882
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发表时间：
2023-11-22
期刊：
影响因子：
5.9
通讯作者：
Li MQ
中科院分区：
文献类型：
--
作者：
Qin XY;Ha SY;Chen L;Zhang T;Li MQ
尽管抗叶酸受体自身抗体（FRAbs）最初是在脑叶酸缺乏症中被发现的，但它与流产等妊娠并发症有关；然而，其潜在机制需要进一步阐明。FRAbs可通过叶酸结合蛋白介导的致敏作用以及叶酸受体（FRs）的基因突变、异常调节或降解而产生。FRAbs可能通过与FRs阻断或结合来干扰叶酸的内化和代谢。有趣的是，不同类型的FRs在母胎界面的滋养层细胞、蜕膜上皮或间质以及巨噬细胞上表达，这意味着FRAbs可能参与成功妊娠所必需的关键事件。因此，我们提出FRAbs可能通过调节滋养层生物功能、胎盘发育、蜕膜化、蜕膜内稳态以及FOLR2⁺巨噬细胞的功能来干扰妊娠的建立和维持。鉴于这些发现，FRAbs可能是病理性妊娠的一个关键因素，在针对妊娠并发症的叶酸补充治疗中应予以慎重考虑。
Though firstly identified in cerebral folate deficiency, autoantibodies against folate receptors (FRAbs) have been implicated in pregnancy complications such as miscarriage; however, the underlying mechanism needs to be further elaborated. FRAbs can be produced via sensitization mediated by folate-binding protein as well as gene mutation, aberrant modulation, or degradation of folate receptors (FRs). FRAbs may interfere with folate internalization and metabolism through blocking or binding with FRs. Interestingly, different types of FRs are expressed on trophoblast cells, decidual epithelium or stroma, and macrophages at the maternal-fetal interface, implying FRAbs may be involved in the critical events necessary for a successful pregnancy. Thus, we propose that FRAbs may disturb pregnancy establishment and maintenance by modulating trophoblastic biofunctions, placental development, decidualization, and decidua homeostasis as well as the functions of FOLR2+ macrophages. In light of these findings, FRAbs may be a critical factor in pathological pregnancy, and deserve careful consideration in therapies involving folic acid supplementation for pregnancy complications.
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影响因子：
--
作者：
Bobrowski-Khoury N;Ramaekers VT;Sequeira JM;Quadros EV
通讯作者：
Quadros EV
中国首例FOLR1基因新突变导致脑叶酸缺乏症患者报告
影响因子：
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作者：
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影响因子：
5.6
作者：
Boutilier AJ;Elsawa SF
通讯作者：
Elsawa SF
影响因子：
5.9
作者：
Bobrowski-Khoury N;Sequeira JM;Quadros EV
通讯作者：
Quadros EV
影响因子：
16.2
作者：
Chen X;Zhang Y;Chen H;Jiang Y;Wang Y;Wang D;Li M;Dou Y;Sun X;Huang G;Yan W
通讯作者：
Yan W