Rapidly Progressive Paraneoplastic Neuropathy Associated with Renal Cell Carcinoma: A Case Report.
Rapidly Progressive Paraneoplastic Neuropathy Associated with Renal Cell Carcinoma: A Case Report.
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DOI：
10.26502/jcsct.5079171
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Khan, Shaida
中科院分区：
文献类型：
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作者：
Shah, Divya;Trivedi, Jaya;Vernino, Steven;Khan, Shaida
副肿瘤神经系统疾病是发生在包括肾细胞癌在内的各种恶性肿瘤中的罕见综合征。副肿瘤神经系统疾病的症状是多种多样的，涉及中枢神经系统、周围神经系统或两者。我们报告了一例下肢弥漫性疼痛，快速进展的不对称运动和感觉症状以及远端上肢萎缩的患者。电诊断提示多发性单神经炎。最初的经验性皮质类固醇治疗并没有导致改善。进一步的诊断显示双侧透明细胞肾癌。血浆置换治疗导致疼痛和肢体力量的显著和快速改善。本病例强调了肾癌中罕见的副肿瘤神经病变，并强调了在出现快速进展的多灶性神经病变的患者中进行恶性肿瘤筛查的重要性。
Paraneoplastic neurological disorders are rare syndromes that occur with various malignancies including renal cell carcinoma. Symptoms of paraneoplastic neurological disorders are diverse and involve either the central nervous system, peripheral nervous system, or both. We present a patient with diffuse limb pain, rapidly progressive asymmetric motor and sensory symptoms and distal upper limb atrophy. Electrodiagnostic testing was suggestive of mononeuritis multiplex. Initial empiric treatment with corticosteroids did not lead to improvement. Further diagnostic studies revealed bilateral clear cell renal carcinoma. Treatment with plasmapheresis led to significant and rapid improvement in pain and limb strength. This case highlights the rare occurrence of paraneoplastic neuropathy in renal cancer and emphasizes the importance of screening for malignancy in patients presenting with rapidly progressive multifocal neuropathy.