Biological effects of radiation on cancer cells.
Biological effects of radiation on cancer cells.
复制标题
辐射对癌细胞的生物学效应
DOI：
10.1186/s40779-018-0167-4
复制
发表时间：
2018-06-30
影响因子：
21.1
通讯作者：
Qian HL
中科院分区：
文献类型：
--
作者：
Wang JS;Wang HJ;Qian HL
随着放射肿瘤学、计算机技术和医学影像技术的发展，放射治疗取得了长足的进步。研究放射对肿瘤的影响及其具体机制已成为肿瘤治疗的中心课题。传统观点认为，辐射可直接影响DNA双螺旋结构，从而激活DNA损伤传感器，诱导细胞凋亡、坏死和衰老，或影响正常的有丝分裂事件，最终重塑肿瘤细胞的各种生物学特性。此外，辐射损伤亚细胞结构，如癌细胞的细胞质膜、内质网、核糖体、线粒体和溶酶体，以调节肿瘤细胞的各种生物活性。最近的研究表明，辐射还可以改变肿瘤细胞的表型、免疫原性和微环境，从而全面改变癌细胞的生物学行为。本文就放射治疗对肿瘤细胞生物学特性的影响进行综述，以期为放射治疗提供理论依据，开创肿瘤学的新纪元。
With the development of radiotherapeutic oncology, computer technology and medical imaging technology, radiation therapy has made great progress. Research on the impact and the specific mechanism of radiation on tumors has become a central topic in cancer therapy. According to the traditional view, radiation can directly affect the structure of the DNA double helix, which in turn activates DNA damage sensors to induce apoptosis, necrosis, and aging or affects normal mitosis events and ultimately rewires various biological characteristics of neoplasm cells. In addition, irradiation damages subcellular structures, such as the cytoplasmic membrane, endoplasmic reticulum, ribosome, mitochondria, and lysosome of cancer cells to regulate various biological activities of tumor cells. Recent studies have shown that radiation can also change the tumor cell phenotype, immunogenicity and microenvironment, thereby globally altering the biological behavior of cancer cells. In this review, we focus on the effects of therapeutic radiation on the biological features of tumor cells to provide a theoretical basis for combinational therapy and inaugurate a new era in oncology.
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影响因子：
4.7
作者：
Demaria S;Formenti SC
通讯作者：
Formenti SC
影响因子：
4.8
作者：
Collis, SJ;Schwaninger, JM;DeWeese, TL
通讯作者：
DeWeese, TL
DOI：
10.1016/j.ijrobp.2013.11.008
发表时间：
2014-03-01
影响因子：
7
作者：
Bayer, Christine;Liebhardt, Michael E.;Multhoff, Gabriele
通讯作者：
Multhoff, Gabriele
影响因子：
4.2
作者：
Ingrosso, Gianluca;Fantini, Massin;Bei, Roberto
通讯作者：
Bei, Roberto
影响因子：
4.8
作者：
Asea, A;Rehli, M;Calderwood, SK
通讯作者：
Calderwood, SK