Hepatitis B- and C-related hepatocellular carcinomas yield different clinical features and prognosis
Hepatitis B- and C-related hepatocellular carcinomas yield different clinical features and prognosis
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DOI：
10.1016/j.ejca.2006.06.007
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发表时间：
2006-10-01
影响因子：
8.4
通讯作者：
Sheu, Jin-Chuan
中科院分区：
文献类型：
--
作者：
Chen, Chien-Hung;Huang, Guan-Tarn;Sheu, Jin-Chuan
本研究的目的是比较B型肝炎病毒相关肝细胞癌（HBV-HCC）和丙型肝炎病毒相关肝细胞癌（HCV-HCC）患者的临床特征和生存率。共纳入2820例HCC患者。HBV-HCC患者的平均年龄为52.5 ± 13.4岁，而HCV-HCC患者的平均年龄为64.8 ± 8.7岁。HBV-HCC的男女比例为7.8，HCV-HCC的男女比例为1.7。HBV-HCC的平均甲胎蛋白水平为11，661 +/-22，805 ng/mL，而HCV-HCC为5079 +/-15，005 ng/mL。HBV-HCC的平均肿瘤大小为6.4 +/- 4.1 cm，而HCV-HCC的平均肿瘤大小为4.6 +/- 3.1 cm。中位生存期HBV-HCC为11.1个月，HCV-HCC为23.9个月。与HBV-HCC患者相比，HCV-HCC患者年龄大，男女比例低，白色细胞计数低，血清白蛋白水平低，血清ALT水平高，血清甲胎蛋白水平低，肿瘤体积小，生存期长。(c)2006爱思唯尔有限公司保留所有权利。
The purpose of this study was to compare the clinical features and survival in patients with hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) and hepatitis C virus-related hepatocellular carcinoma (HCV-HCC). A total of 2820 HCC patients were included. The mean age of HBV-HCC patients was 52.5 +/- 13.4 years, while it was 64.8 +/- 8.7 years in HCV-HCC patients. The male/female ratio was 7.8 in HBV-HCC, while it was 1.7 in HCV-HCC. The mean alpha-fetoprotein level in HBV-HCC was 11,661 +/- 22,805 ng/mL, while it was 5079 +/- 15,005 ng/mL in HCV-HCC. The mean tumour size was 6.4 +/- 4.1 cm in HBV-HCC, while it was 4.6 +/- 3.1 cm in HCV-HCC. The median survival was 11.1 months in HBV-HCC, while it was 23.9 months in HCV-HCC. Compared with HBV-HCC patients, HCV-HCC patients were older, had a lower male/female ratio, lower white blood cell count, lower serum albumin level, higher serum ALT level, lower serum alpha-fetoprotein level, smaller tumour size and survived longer. (c) 2006 Elsevier Ltd. All rights reserved.