Adrenal androgen production in response to adrenocorticotropin infusions in men.
Adrenal androgen production in response to adrenocorticotropin infusions in men.
复制标题
男性因促肾上腺皮质激素输注而产生肾上腺雄激素。
DOI：
10.1080/07435809609043767
复制
发表时间：
1996
影响因子：
2.1
通讯作者：
Boots,LR
中科院分区：
文献类型：
--
作者：
ParkerJr,CR;Azziz,R;Potter,HD;Boots,LR
在一组健康青年男性中，研究了几种肾上腺皮质激素对促肾上腺皮质激素（ACTH）的反应。该方案包括用地塞米松抑制肾上腺皮质过夜，然后以30 - 30，720 ng/1.5 M2的递增（4X）剂量输注ACTH 1小时，然后输注0.25 mg ACTH/1.5 M2。而皮质醇、雄烯二酮和雄烯二醇浓度在较高ACTH输注速率下趋于平稳，脱氢表雄酮（DHEA）和17-羟孕酮（17-OH P）则无此作用。最高剂量ACTH后达到的皮质醇浓度比基线高50倍以上。DHEA水平上升到基线值的约13倍，而其他类固醇增加到较小的程度（3-5倍）。从剂量反应曲线外推每种类固醇显著增加超过基线水平所需的ACTH输注速率，并将其视为每种类固醇对ACTH敏感性的指标。皮质醇最敏感，在约35 ng ACTH/1.5M2时显著升高，其次是雄烯二醇、DHEA、雄烯二酮和17-OH P。
The responses of several adrenal steroids to adrenocorticotropin (ACTH) were investigated in a group of healthy young men. The protocol consisted of overnight adrenal suppression with dexamethasone followed by 1 hr infusions of ACTH in increasing (4X) doses ranging from 30 – 30,720 ng/1.5M2followed by 0.25 mg ACTH/1.5M2.Whereas cortisol, androstenedione and androstenediol concentrations tended to plateau at the higher ACTH infusion rates, those of dehydroepiandrosterone (DHEA) and 17-hydroxyprogesterone (17-OH P) did not. The cortisol concentration achieved after the highest dose of ACTH was over 50 fold higher than that at baseline. DHEA levels rose to values about 13 times baseline whereas the other steroids increased to lesser extents (3-5 fold). The ACTH infusion rate required to significantly increase each steroid over the baseline level was extrapolated from dose response curves and was considered to be an index of the sensitivity of each steroid to ACTH. Cortisol was the most sensitive, rising significantly at approximately 35 ng ACTH/1.5M2, followed by androstenediol, DHEA, androstenedione and 17-OH P.